Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DK046335-04
Application #
2145517
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1993-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Texas A&M University
Department
Chemistry
Type
Schools of Earth Sciences/Natur
DUNS #
City
College Station
State
TX
Country
United States
Zip Code
77845
Lim, Kwang Hun; Dasari, Anvesh K R; Hung, Ivan et al. (2016) Structural Changes Associated with Transthyretin Misfolding and Amyloid Formation Revealed by Solution and Solid-State NMR. Biochemistry 55:1941-4
Baranczak, Aleksandra; Liu, Yu; Connelly, Stephen et al. (2015) A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans. J Am Chem Soc 137:7404-14
Cho, Younhee; Baranczak, Aleksandra; Helmke, Stephen et al. (2015) Personalized medicine approach for optimizing the dose of tafamidis to potentially ameliorate wild-type transthyretin amyloidosis (cardiomyopathy). Amyloid 22:175-80
Eisele, Yvonne S; Monteiro, Cecilia; Fearns, Colleen et al. (2015) Targeting protein aggregation for the treatment of degenerative diseases. Nat Rev Drug Discov 14:759-80
Baranczak, Aleksandra; Connelly, Stephen; Liu, Yu et al. (2014) Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging--what we know and what we need to learn. Biopolymers 101:484-95
Rappley, Irit; Monteiro, CecĂ­lia; Novais, Marta et al. (2014) Quantification of transthyretin kinetic stability in human plasma using subunit exchange. Biochemistry 53:1993-2006
Liu, Yu; Zhang, Xin; Tan, Yun Lei et al. (2014) De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters. J Am Chem Soc 136:13102-5
Zhang, Xin; Liu, Yu; Genereux, Joseph C et al. (2014) Heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli. ACS Chem Biol 9:1945-9
Grimster, Neil P; Connelly, Stephen; Baranczak, Aleksandra et al. (2013) Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate. J Am Chem Soc 135:5656-68
Myung, Nojoon; Connelly, Stephen; Kim, Boyoung et al. (2013) Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors. Chem Commun (Camb) 49:9188-9190

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