Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DK048816-02
Application #
2149287
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1995-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Missouri-Columbia
Department
Miscellaneous
Type
Other Domestic Higher Education
DUNS #
112205955
City
Columbia
State
MO
Country
United States
Zip Code
65211
Walker, Nancy M; Liu, Jinghua; Stein, Sydney R et al. (2016) Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium. Am J Physiol Gastrointest Liver Physiol 310:G70-80
Liu, Jinghua; Walker, Nancy M; Ootani, Akifumi et al. (2015) Defective goblet cell exocytosis contributes to murine cystic fibrosis-associated intestinal disease. J Clin Invest 125:1056-68
Liu, Jinghua; Walker, Nancy M; Cook, Matthew T et al. (2012) Functional Cftr in crypt epithelium of organotypic enteroid cultures from murine small intestine. Am J Physiol Cell Physiol 302:C1492-503
Alper, Seth L; Stewart, Andrew K; Vandorpe, David H et al. (2011) Native and recombinant Slc26a3 (downregulated in adenoma, Dra) do not exhibit properties of 2Cl-/1HCO3- exchange. Am J Physiol Cell Physiol 300:C276-86
Hug, Martin J; Clarke, Lane L; Gray, Michael A (2011) How to measure CFTR-dependent bicarbonate transport: from single channels to the intact epithelium. Methods Mol Biol 741:489-509
Walker, N M; Simpson, J E; Hoover, E E et al. (2011) Functional activity of Pat-1 (Slc26a6) Cl(?)/HCO?(?) exchange in the lower villus epithelium of murine duodenum. Acta Physiol (Oxf) 201:21-31
Simpson, Janet E; Walker, Nancy M; Supuran, Claudiu T et al. (2010) Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium. Am J Physiol Gastrointest Liver Physiol 298:G683-91
Catalan, Marcelo A; Nakamoto, Tetsuji; Gonzalez-Begne, Mireya et al. (2010) Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland. J Physiol 588:713-24
Clarke, Lane L (2009) A guide to Ussing chamber studies of mouse intestine. Am J Physiol Gastrointest Liver Physiol 296:G1151-66
Walker, Nancy M; Simpson, Janet E; Brazill, Jennifer M et al. (2009) Role of down-regulated in adenoma anion exchanger in HCO3- secretion across murine duodenum. Gastroenterology 136:893-901

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