Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29DK051091-01
Application #
2152203
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1996-06-01
Project End
2001-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Bresson, Damien; Fradkin, Matthew; Manenkova, Yulia et al. (2010) Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes. Mol Ther 18:307-16
Horwitz, Marshall S; Efrat, Shimon; Christen, Urs et al. (2009) Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes. Proc Natl Acad Sci U S A 106:19450-4
Ejrnaes, Mette; Videbaek, Nicoline; Christen, Urs et al. (2005) Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics. J Immunol 174:2746-55
Christen, Urs; Darwiche, Rima; Thomas, Helen E et al. (2004) Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells. Diabetes 53:591-6
Christen, Urs; Benke, Dirk; Wolfe, Tom et al. (2004) Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient. J Clin Invest 113:74-84
Petersen, J S; Bregenholt, S; Apostolopolous, V et al. (2003) Coupling of oral human or porcine insulin to the B subunit of cholera toxin (CTB) overcomes critical antigenic differences for prevention of type I diabetes. Clin Exp Immunol 134:38-45
von Herrath, Matthias G; Bot, Adrian (2003) Immune responsiveness, tolerance and dsRNA: implications for traditional paradigms. Trends Immunol 24:289-93
Bot, A; Rodrigo, E; Wolfe, T et al. (2003) Infection-triggered regulatory mechanisms override the role of STAT 4 in control of the immune response to influenza virus antigens. J Virol 77:5794-800
Christen, Urs; McGavern, Dorian B; Luster, Andrew D et al. (2003) Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease. J Immunol 171:6838-45
Asseman, C; von Herrath, M (2002) About CD4pos CD25pos regulatory cells. Autoimmun Rev 1:190-7

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