Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29EY011231-01
Application #
2165542
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1996-02-01
Project End
2001-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Biochemistry
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Micali, E; Chehade, K A; Isaacs, R J et al. (2001) Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups. Biochemistry 40:12254-65
Than, C; Morimoto, H; Williams, P G et al. (2001) Preparation, NMR characterization, and labeling reactions of tritiated triacetoxy sodium borohydride. J Org Chem 66:3602-5
Finlin, B S; Shao, H; Kadono-Okuda, K et al. (2000) Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. Biochem J 347 Pt 1:223-31
Shao, H; Andres, D A (2000) A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras. J Biol Chem 275:26914-24
Rusyn, E V; Reynolds, E R; Shao, H et al. (2000) Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways. Oncogene 19:4685-94
Andres, D A; Crick, D C; Finlin, B S et al. (1999) Rapid identification of cysteine-linked isoprenyl groups by metabolic labeling with [3H]farnesol and [3H]geranylgeraniol. Methods Mol Biol 116:107-23
Finlin, B S; Andres, D A (1999) Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins. Arch Biochem Biophys 368:401-12
Shao, H; Kadono-Okuda, K; Finlin, B S et al. (1999) Biochemical characterization of the Ras-related GTPases Rit and Rin. Arch Biochem Biophys 371:207-19
Kadono-Okuda, K; Andres, D A (1997) An expression cloning method to identify monomeric GTP-binding proteins by GTP overlay. Anal Biochem 254:187-91
Crick, D C; Andres, D A; Waechter, C J (1997) Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation. Biochem Biophys Res Commun 237:483-7

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