Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29EY011305-01
Application #
2165627
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1995-12-07
Project End
2000-11-30
Budget Start
1995-12-07
Budget End
1996-11-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Emory University
Department
Genetics
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Brown, Michael D; Starikovskaya, Elena; Derbeneva, Olga et al. (2002) The role of mtDNA background in disease expression: a new primary LHON mutation associated with Western Eurasian haplogroup J. Hum Genet 110:130-8
Brown, M D; Allen, J C; Van Stavern, G P et al. (2001) Clinical, genetic, and biochemical characterization of a Leber hereditary optic neuropathy family containing both the 11778 and 14484 primary mutations. Am J Med Genet 104:331-8
Brown, M D; Zhadanov, S; Allen, J C et al. (2001) Novel mtDNA mutations and oxidative phosphorylation dysfunction in Russian LHON families. Hum Genet 109:33-9
Brown, M D; Trounce, I A; Jun, A S et al. (2000) Functional analysis of lymphoblast and cybrid mitochondria containing the 3460, 11778, or 14484 Leber's hereditary optic neuropathy mitochondrial DNA mutation. J Biol Chem 275:39831-6
Brown, M D (1999) The enigmatic relationship between mitochondrial dysfunction and Leber's hereditary optic neuropathy. J Neurol Sci 165:1-5
Biousse, V; Brown, M D; Newman, N J et al. (1997) De novo 14484 mitochondrial DNA mutation in monozygotic twins discordant for Leber's hereditary optic neuropathy. Neurology 49:1136-8
Brown, M D; Sun, F; Wallace, D C (1997) Clustering of Caucasian Leber hereditary optic neuropathy patients containing the 11778 or 14484 mutations on an mtDNA lineage. Am J Hum Genet 60:381-7
Muth, J; Williams, P M; Williams, S J et al. (1996) Fast capillary electrophoresis-laser induced fluorescence analysis of ligase chain reaction products: human mitochondrial DNA point mutations causing Leber's hereditary optic neuropathy. Electrophoresis 17:1875-83