Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29GM037631-06
Application #
3466039
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1987-04-01
Project End
1992-03-31
Budget Start
1992-01-01
Budget End
1992-03-31
Support Year
6
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Wollert, P S; Menconi, M J; O'Sullivan, B P et al. (1993) LY255283, a novel leukotriene B4 receptor antagonist, limits activation of neutrophils and prevents acute lung injury induced by endotoxin in pigs. Surgery 114:191-8
Fink, M P; O'Sullivan, B P; Menconi, M J et al. (1993) Effect of granulocyte colony-stimulating factor on systemic and pulmonary responses to endotoxin in pigs. J Trauma 34:571-7;discussion 577-8
Fink, M P; O'Sullivan, B P; Menconi, M J et al. (1993) A novel leukotriene B4-receptor antagonist in endotoxin shock: a prospective, controlled trial in a porcine model. Crit Care Med 21:1825-37
Fink, M P; Kaups, K L; Wang, H et al. (1992) Ibuprofen improves survival but does not ameliorate increased gut mucosal permeability in endotoxic pigs. Arch Surg 127:49-53;discussion 53-4
Cohn, S M; Kruithoff, K L; Rothschild, H R et al. (1991) Leukotriene C4 induces mesenteric hypoperfusion and intestinal intramural acidosis in pigs. J Surg Res 50:303-7
Fink, M P; Kruithoff, K L; Antonsson, J B et al. (1991) Delayed treatment with an LTD4/E4 antagonist limits pulmonary edema in endotoxic pigs. Am J Physiol 260:R1007-13
Cohn, S M; Kruithoff, K L; Rothschild, H R et al. (1991) Beneficial effects of LY203647, a novel leukotriene C4/D4 antagonist, on pulmonary function and mesenteric perfusion in a porcine model of endotoxic shock and ARDS. Circ Shock 33:7-16
Heard, S O; Baum, T D; Wang, H L et al. (1991) Systemic and mesenteric O2 metabolism in endotoxic pigs: effect of graded hemorrhage. Circ Shock 35:44-52
Fink, M P; Antonsson, J B; Wang, H L et al. (1991) Increased intestinal permeability in endotoxic pigs. Mesenteric hypoperfusion as an etiologic factor. Arch Surg 126:211-8
Heard, S O; Baum, T D; Feldman, H S et al. (1991) Lipopolysaccharide-induced myocardial depression is not mediated by cyclooxygenase products. Crit Care Med 19:723-7

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