The theory underlying our understanding of genetic differences between human populations relies implicitly on an assumption that emigration is """"""""unstructured"""""""", i.e. that emigrant allele frequencies are distributed as though emigrants were drawn at random without replacement from their group of origin (Rogers and Harpending 1986). There is extensive evidence, however, that this assumption is often violated in nature, and theoretical studies have shown that such violations may have substantial effects on genetic differences between groups (Fix 1978; Leslie 1980; Rogers and Jorde in press; Rogers in press). The proposed research will estimate the magnitude of these violations in 24 populations and use the theoretical work just cited to assess their effect on genetic population differences.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM039593-06
Application #
3466872
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1988-07-01
Project End
1993-01-31
Budget Start
1992-02-01
Budget End
1993-01-31
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
Schools of Arts and Sciences
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Manderscheid, E J; Brannan, J A; Rogers, A R (1994) Is migration kin structured? Hum Biol 66:49-57
O'Brien, E; Kerber, R A; Jorde, L B et al. (1994) Founder effect: assessment of variation in genetic contributions among founders. Hum Biol 66:185-204
Sherry, S T; Rogers, A R; Harpending, H et al. (1994) Mismatch distributions of mtDNA reveal recent human population expansions. Hum Biol 66:761-75
Rogers, A R (1991) Doubts about isonymy. Hum Biol 63:663-8
Rogers, A R (1988) Three components of genetic drift in subdivided populations. Am J Phys Anthropol 77:435-49
Rogers, A R; Eriksson, A W (1988) Statistical analysis of the migration component of genetic drift. Am J Phys Anthropol 77:451-7