Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM041935-05
Application #
2181140
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1991-04-01
Project End
1997-03-31
Budget Start
1995-04-01
Budget End
1997-03-31
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Other Health Professions
Type
Schools of Pharmacy
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Zalups, Rudolfs K; Joshee, Lucy; Bridges, Christy C (2014) Novel Hg2+-induced nephropathy in rats and mice lacking Mrp2: evidence of axial heterogeneity in the handling of Hg2+ along the proximal tubule. Toxicol Sci 142:250-60
Marion, Tracy L; Perry, Cassandra H; St Claire 3rd, Robert L et al. (2012) Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes. Toxicol Appl Pharmacol 261:1-9
Marion, Tracy L; Perry, Cassandra H; St Claire 3rd, Robert L et al. (2011) Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes. Toxicol Sci 120:371-80
Yue, Wei; Lee, Jin Kyung; Abe, Koji et al. (2011) Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR?) rats. Drug Metab Dispos 39:441-7
Wolf, Kristina K; Vora, Sapana; Webster, Lindsey O et al. (2010) Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport. Toxicol In Vitro 24:297-309
Lee, Jin Kyung; Marion, Tracy L; Abe, Koji et al. (2010) Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation. J Pharmacol Exp Ther 332:26-34
Yue, Wei; Abe, Koji; Brouwer, Kim L R (2009) Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion. Mol Pharm 6:134-43
Abe, Koji; Bridges, Arlene S; Brouwer, Kim L R (2009) Use of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors. Drug Metab Dispos 37:447-52