Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM045026-05
Application #
2182933
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1992-05-01
Project End
1998-06-30
Budget Start
1996-05-01
Budget End
1998-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wichita State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Wichita
State
KS
Country
United States
Zip Code
67260
Wimalasena, K; Wimalasena, D S; Dharmasena, S et al. (1997) Chiral multisubstrate inhibitors of dopamine beta-monooxygenase: evidence for dual modes of interaction. Biochemistry 36:7144-53
Wimalasena, K; Haines, D C (1996) A general progress curve method for the kinetic analysis of suicide enzyme inhibitors. Anal Biochem 234:175-82
Wimalasena, K; Dharmasena, S; Wimalasena, D S (1994) Ascorbate based novel high affinity alternate reductants and competitive inhibitors of dopamine beta-monooxygenase. Biochem Biophys Res Commun 200:113-9
Wimalasena, K; Dharmasena, S (1994) Substrate specificity of ascorbate oxidase: unexpected similarity to the reduction site of dopamine beta-monooxygenase. Biochem Biophys Res Commun 203:1471-6
Wimalasena, K; Dharmasena, S (1993) Continuous spectrophotometric assay for ascorbate oxidase based on a novel chromophoric substrate, 2-aminoascorbic acid. Anal Biochem 210:58-62