Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29GM046354-05
Application #
2183832
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1991-09-30
Project End
1997-04-30
Budget Start
1996-01-01
Budget End
1996-04-30
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Rhode Island Hospital (Providence, RI)
Department
Type
DUNS #
161202122
City
Providence
State
RI
Country
United States
Zip Code
02903
Huang, Xin; Chen, Yaping; Chung, Chun-Shiang et al. (2014) Identification of B7-H1 as a novel mediator of the innate immune/proinflammatory response as well as a possible myeloid cell prognostic biomarker in sepsis. J Immunol 192:1091-9
Ayala, Alfred; Elphick, Gwendolyn F; Kim, Ye Sul et al. (2014) Sepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency. J Innate Immun 6:325-38
Shubin, Nicholas J; Monaghan, Sean F; Ayala, Alfred (2011) Anti-inflammatory mechanisms of sepsis. Contrib Microbiol 17:108-24
Newsome, Courtni T; Flores, Estefany; Ayala, Alfred et al. (2011) Improved antimicrobial host defense in mice following poly-(1,6)-?-D-glucopyranosyl-(1,3)-?-D-glucopyranose glucan treatment by a gender-dependent immune mechanism. Clin Vaccine Immunol 18:2043-9
Guignant, Caroline; Lepape, Alain; Huang, Xin et al. (2011) Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients. Crit Care 15:R99
Huang, Xin; Venet, Fabienne; Wang, Yvonne L et al. (2009) PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Proc Natl Acad Sci U S A 106:6303-8
Zhu, X H; Zellweger, R; Wichmann, M W et al. (1997) Effects of prolactin and metoclopramide on macrophage cytokine gene expression in late sepsis. Cytokine 9:437-46
Ayala, A; O'Neill, P J; Uebele, S A et al. (1997) Mechanism of splenic immunosuppression during sepsis: key role of Kupffer cell mediators. J Trauma 42:882-8
Williams, T E; Ayala, A; Chaudry, I H (1997) Inducible macrophage apoptosis following sepsis is mediated by cysteine protease activation and nitric oxide release. J Surg Res 70:113-8
Zellweger, R; Wichmann, M W; Ayala, A et al. (1997) Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males. Crit Care Med 25:106-10

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