Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29GM051996-01A2
Application #
2190832
Study Section
Special Emphasis Panel (ZRG2-GEN (05))
Project Start
1996-06-01
Project End
2001-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
New York Medical College
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Valhalla
State
NY
Country
United States
Zip Code
10595
Carroll, Sarah M; Hampton, Randolph Y (2010) Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. J Biol Chem 285:5146-56
Bazirgan, Omar A; Hampton, Randolph Y (2008) Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo. J Biol Chem 283:12797-810
Sato, Brian K; Hampton, Randolph Y (2006) Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis. Yeast 23:1053-64
Bazirgan, Omar A; Garza, Renee M; Hampton, Randolph Y (2006) Determinants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase. J Biol Chem 281:38989-9001
Hampton, Randolph Y (2005) Fusion-based strategies to identify genes involved in degradation of a specific substrate. Methods Enzymol 399:310-23
Flury, Isabelle; Garza, Renee; Shearer, Alexander et al. (2005) INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. EMBO J 24:3917-26
Shearer, Alexander G; Hampton, Randolph Y (2005) Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. EMBO J 24:149-59
Federovitch, Christine M; Ron, David; Hampton, Randolph Y (2005) The dynamic ER: experimental approaches and current questions. Curr Opin Cell Biol 17:409-14
Shearer, Alexander G; Hampton, Randolph Y (2004) Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase. J Biol Chem 279:188-96