Synaptic Mechanisms of General Anesthetics in the CNS

Hemmings, Hugh C.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29GM052441-02
• Application #: 2191469
• Study Section: Surgery, Anesthesiology and Trauma Study Section (SAT)
• Project Start: 1995-09-30
• Project End: 2000-09-29
• Budget Start: 1996-09-30
• Budget End: 1997-09-29
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: Weill Medical College of Cornell University
• Department: Anesthesiology
• Type: Schools of Medicine
• DUNS #: 201373169
• City: New York
• State: NY
• Country: United States
• Zip Code: 10065

Publications

Hemmings Jr, H C (1998) General anesthetic effects on protein kinase C. Toxicol Lett 100-101:89-95

Ratnakumari, L; Hemmings Jr, H C (1998) Inhibition of presynaptic sodium channels by halothane. Anesthesiology 88:1043-54

Murugaiah, K D; Hemmings Jr, H C (1998) Effects of intravenous general anesthetics on [3H]GABA release from rat cortical synaptosomes. Anesthesiology 89:919-28

Ratnakumari, L; Hemmings Jr, H C (1997) Effects of propofol on sodium channel-dependent sodium influx and glutamate release in rat cerebrocortical synaptosomes. Anesthesiology 86:428-39

Hemmings Jr, H C; Adamo, A I (1997) Effect of halothane on conventional protein kinase C translocation and down-regulation in rat cerebrocortical synaptosomes. Br J Anaesth 78:189-96

Ratnakumari, L; Hemmings Jr, H C (1996) Inhibition by propofol of [3H]-batrachotoxinin-A 20-alpha-benzoate binding to voltage-dependent sodium channels in rat cortical synaptosomes. Br J Pharmacol 119:1498-504