Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29GM054038-01
Application #
2193433
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1996-05-01
Project End
2001-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Tamir, Sagi; Paddock, Mark L; Darash-Yahana-Baram, Merav et al. (2015) Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease. Biochim Biophys Acta 1853:1294-315
Tamir, Sagi; Rotem-Bamberger, Shahar; Katz, Chen et al. (2014) Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1. Proc Natl Acad Sci U S A 111:5177-82
Tamir, Sagi; Eisenberg-Domovich, Yael; Conlan, Andrea R et al. (2014) A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties. Acta Crystallogr D Biol Crystallogr 70:1572-8
Sohn, Yang-Sung; Tamir, Sagi; Song, Luhua et al. (2013) NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth. Proc Natl Acad Sci U S A 110:14676-81
Baxter, Elizabeth Leigh; Zuris, John A; Wang, Charles et al. (2013) Allosteric control in a metalloprotein dramatically alters function. Proc Natl Acad Sci U S A 110:948-53
Tamir, Sagi; Zuris, John A; Agranat, Lily et al. (2013) Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs. PLoS One 8:e61202
Barkho, Sulyman; Pierce, Levi C T; McGlone, Maria L et al. (2013) Distal loop flexibility of a regulatory domain modulates dynamics and activity of C-terminal SRC kinase (csk). PLoS Comput Biol 9:e1003188
Capraro, Dominique T; Roy, Melinda; Onuchic, José N et al. (2012) ?-Bulge triggers route-switching on the functional landscape of interleukin-1?. Proc Natl Acad Sci U S A 109:1490-3
Capraro, Dominique T; Gosavi, Shachi; Roy, Melinda et al. (2012) Folding circular permutants of IL-1ýý: route selection driven by functional frustration. PLoS One 7:e38512
Haglund, Ellinor; Sulkowska, Joanna I; He, Zhao et al. (2012) The unique cysteine knot regulates the pleotropic hormone leptin. PLoS One 7:e45654

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