Abstract

In this FIRST award proposal, the investigator proposes to use a rat model of postoperative pain that he has developed. He will test the hypothesis that incisional tissue injury results in a different form of spinal sensitization than that observed in other pain models. In parallel behavioral studies of mechanical hyper-algesia and single unit neurophysiology of spinal dorsal horn neurons, he will examine dorsal horn neuron threshold, receptive field size and background activity before and after incision; the effect of excitatory amino acid antagonists on the hyperalgesia; and the effect of the same antagonists on the sensitized spinal neurons.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM055831-04
Application #
6180749
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Cole, Alison E
Project Start
1997-05-01
Project End
2002-04-30
Budget Start
2000-05-01
Budget End
2001-04-30
Support Year
4
Fiscal Year
2000
Total Cost
$93,862
Indirect Cost

  Institution

Name
University of Iowa
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Xu, Jun; Brennan, Timothy J (2011) The pathophysiology of acute pain: animal models. Curr Opin Anaesthesiol 24:508-14
Kang, Sinyoung; Wu, Chaoran; Banik, Ratan K et al. (2010) Effect of capsaicin treatment on nociceptors in rat glabrous skin one day after plantar incision. Pain 148:128-40
Xu, Jun; Brennan, Timothy J (2010) Guarding pain and spontaneous activity of nociceptors after skin versus skin plus deep tissue incision. Anesthesiology 112:153-64
Wu, Chaoran; Erickson, Mark A; Xu, Jun et al. (2009) Expression profile of nerve growth factor after muscle incision in the rat. Anesthesiology 110:140-9
Kang, Sinyoung; Brennan, Timothy J (2009) Chemosensitivity and mechanosensitivity of nociceptors from incised rat hindpaw skin. Anesthesiology 111:155-64
Xu, Jun; Brennan, Timothy J (2009) Comparison of skin incision vs. skin plus deep tissue incision on ongoing pain and spontaneous activity in dorsal horn neurons. Pain 144:329-39
Xu, Jun; Richebe, Philippe; Brennan, Timothy J (2009) Separate groups of dorsal horn neurons transmit spontaneous activity and mechanosensitivity one day after plantar incision. Eur J Pain 13:820-8
Banik, Ratan K; Brennan, Timothy J (2009) Trpv1 mediates spontaneous firing and heat sensitization of cutaneous primary afferents after plantar incision. Pain 141:41-51
Hamalainen, Minna M; Subieta, Alberto; Arpey, Christopher et al. (2009) Differential effect of capsaicin treatment on pain-related behaviors after plantar incision. J Pain 10:637-45
Zahn, P K; Umali, E; Brennan, T J (1998) Intrathecal non-NMDA excitatory amino acid receptor antagonists inhibit pain behaviors in a rat model of postoperative pain. Pain 74:213-23

Showing the most recent 10 out of 11 publications