Gastroesophageal reflux of infancy is a common disorder which can have serious consequences. Despite its frequent occurrence during the newborn period, we understand little about the developmental factors that predispose the infant to gastroesophageal reflux. This project will examine the age related changes in mechanical properties and neurohumoral modulation of motility in the upper gastrointestinal tract. It will define the effect of developmental changes in shape, size, and geometry on the ability of the upper gastrointestinal tract to develop forces and pressures. The effects of these changes will be assessed through: 1). In vitro examination of tissue to determine force length and stress strain relationships of the developing esophagus, stomach, and their sphincters. 2). Isolated muscle cell techniques to determine the effect of age on cell size and the responsiveness to proposed neurohumoral transmitters. 3). In vivo studies to evaluate the effect of age on: a) Maintenance and modulation of upper esophageal sphincter, lower esophageal sphincter tone and relaxation, and esophageal peristalsis. b) Development of pressure volume relationships in the stomach. This systematic approach to age related changes in upper gastrointestinal motility will lead to more rational therapy for the common clinical problem of gastroesophageal reflux during infancy.

Project Start
1986-08-01
Project End
1991-07-31
Budget Start
1988-08-01
Budget End
1989-07-31
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Biancani, P; Harnett, K M; Sohn, U D et al. (1994) Differential signal transduction pathways in cat lower esophageal sphincter tone and response to ACh. Am J Physiol 266:G767-74
Hillemeier, C; Bitar, K N; Marshall, J M et al. (1991) Intracellular pathways for contraction in gastroesophageal smooth muscle cells. Am J Physiol 260:G770-5
Hillemeier, A C; Bitar, K N; Biancani, P (1991) Developmental characteristics of the kitten antrum. Gastroenterology 101:339-43
Hillemeier, C; Biancani, P (1989) Developmental differences in neurohumoral modulation of the cat lower esophageal sphincter. Pediatr Res 26:39-42