Eating disorders especially binge eating are prevalent in obese and non-obese American women. Previous studies have suggested that the temporal pattern of eating has a significant impact on insulin metabolism in that more frequent small meals rapidly result in lower mean insulin levles as opposed to the customary three meals per day. There are strikingly common elements in women who have binge eating disorders and women who have polycystic ovarian syndrome (PCOS) namely that both may have disordered insulin metabolism, increased ovarian androgen secretion, and oligomenorrhea. Because a primary genetic defect has been found only in a subset of PCOS individuals, the proposed studies will attempt to establish a binge-eating hyperinsulinemia experimental model to assess the effects of insulin on gonadotropin secretory dynamics, ovarian androgen responsiveness to gonadotropins, and altered lipid levels.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HD033509-04
Application #
2673913
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1995-09-01
Project End
2000-08-31
Budget Start
1998-09-01
Budget End
1999-08-31
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Evans, William S; Taylor, Ann E; Boyd, David G et al. (2007) Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome. Fertil Steril 88:118-24
Taylor, A E (2000) The gonadotropic axis in hyperandrogenic adolescents. J Pediatr Endocrinol Metab 13 Suppl 5:1281-4
Taylor, A E; Hubbard, J; Anderson, E J (1999) Impact of binge eating on metabolic and leptin dynamics in normal young women. J Clin Endocrinol Metab 84:428-34
Taylor, A E (1998) Polycystic ovary syndrome. Endocrinol Metab Clin North Am 27:877-902, ix