The proposed research will provide data on plasma skimming from in vitro experiments. Two geometries will be investigated, two bifurcations in series, and single bifurcations with unequal branch diameters. Measurements of red cell velocity and red cell flux in each branch will be performed using the red cell fluorescent labeling technique of Sarelius and Duling (1982). The data from this research will be helpful to in vivo microcirculationists and those researchers developing computer models to analyze hemodynamics in branching networks. In vivo microcirculationists will be better equipped to interpret their experimental results on network blood flow. The proposed experiments will provide computer modelers with data on the partition of red cells in vessel junctions. These data will fill one of the major needs to improve current models (Popel, 1980). This research is applicable to the physiological problems of blood flow regulation and oxygen delivery. It also has application to computer simulation experiments, which cannot be performed in vivo, in vascular disease research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL038313-02
Application #
3471089
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1987-08-01
Project End
1991-07-31
Budget Start
1988-08-01
Budget End
1989-07-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of New Hampshire
Department
Type
DUNS #
111089470
City
Durham
State
NH
Country
United States
Zip Code
03824
Boonyasrisawat, Watip; Eberle, Delphine; Bacci, Simonetta et al. (2007) Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes. Diabetes 56:499-505
Carr, R T; Wickham, L L (1991) Influence of vessel diameter on red cell distribution at microvascular bifurcations. Microvasc Res 41:184-96
Rong, F W; Carr, R T (1990) Dye studies on flow through branching tubes. Microvasc Res 39:186-202
Carr, R T; Wickham, L L (1990) Plasma skimming in serial microvascular bifurcations. Microvasc Res 40:179-90
Carr, R T (1989) Estimation of hematocrit profile symmetry recovery length downstream from a bifurcation. Biorheology 26:907-20