Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL046416-05
Application #
2222911
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1992-03-15
Project End
1997-02-28
Budget Start
1996-04-01
Budget End
1997-02-28
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Schade, Alicia J; Arya, Maneesh; Gao, Shan et al. (2003) Cytoplasmic truncation of glycoprotein Ib alpha weakens its interaction with von Willebrand factor and impairs cell adhesion. Biochemistry 42:2245-51
Dong, J F; Berndt, M C; Schade, A et al. (2001) Ristocetin-dependent, but not botrocetin-dependent, binding of von Willebrand factor to the platelet glycoprotein Ib-IX-V complex correlates with shear-dependent interactions. Blood 97:162-8
Dong , J; Ye, P; Schade, A J et al. (2001) Tyrosine sulfation of glycoprotein I(b)alpha. Role of electrostatic interactions in von Willebrand factor binding. J Biol Chem 276:16690-4
Afshar-Kharghan, V; Gineys, G; Schade, A J et al. (2000) Necessity of conserved asparagine residues in the leucine-rich repeats of platelet glycoprotein Ib alpha for the proper conformation and function of the ligand-binding region. Biochemistry 39:3384-91
Dong, J; Schade, A J; Romo, G M et al. (2000) Novel gain-of-function mutations of platelet glycoprotein IBalpha by valine mutagenesis in the Cys209-Cys248 disulfide loop. Functional analysis under statis and dynamic conditions. J Biol Chem 275:27663-70
Dong, J; Li, C; Schade, A J et al. (2000) Mutation in the leucine-rich repeat of platelet glycoprotein Ib alpha results in defects in its interaction with immobilized von Willebrand factor under flow. Chin Med J (Engl) 113:693-8
Dong, J F; Gao, S; Lopez, J A (1998) Synthesis, assembly, and intracellular transport of the platelet glycoprotein Ib-IX-V complex. J Biol Chem 273:31449-54
Dong, J F; Li, C Q; Sae-Tung, G et al. (1997) The cytoplasmic domain of glycoprotein (GP) Ibalpha constrains the lateral diffusion of the GP Ib-IX complex and modulates von Willebrand factor binding. Biochemistry 36:12421-7
Dong, J F; Sae-Tung, G; Lopez, J A (1997) Role of glycoprotein V in the formation of the platelet high-affinity thrombin-binding site. Blood 89:4355-63
Afshar-Kharghan, V; Lopez, J A (1997) Bernard-Soulier syndrome caused by a dinucleotide deletion and reading frameshift in the region encoding the glycoprotein Ib alpha transmembrane domain. Blood 90:2634-43

Showing the most recent 10 out of 18 publications