This research will apply advanced MR techniques, Projection Reconstruction (PR MR), Compact Spin Echo (CSE), and warp Spoiled GRASS (SPGR), to three models of lung disease: pulmonary metastases (focal nodules), pulmonary perfusion abnormalities (emboli) and chronic diffuse lung disease (idiopathic pulmonary fibrosis; IPF). The objectives are to test the sensitivity and specificity of these MR sequences compared with current """"""""gold standards"""""""" provided by CT for nodules, and by radionuclide scans for pulmonary emboli. We will also evaluate the utility of these MR sequences in identifying IPF and in distinguishing inflammatory from fibrotic stages of the disease. Two independent radiologists, blind to the """"""""gold standard"""""""" images, will evaluate: (1) PR MR, CSE and conventional MR images for number, size and location of pulmonary nodules in humans, (2a) PR MR and SPGR images for emboli in a canine model and in humans, (2b) CSE images for susceptibility changes in perfusion defects; and, (3) PR MR, CSE and conventional MR images in patients with IPF and healthy control subjects. Results for each imaging modality will be compared with the """"""""gold standard"""""""" using Wilcoxin and Spearman Ranked Correlation tests. The success of this MR research will directly lead to improved, noninvasive and cost-effective alternatives to existing diagnostic lung imaging procedures that currently depend on ionizing radiation.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL048854-04
Application #
2224948
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1992-07-13
Project End
1996-08-31
Budget Start
1994-09-30
Budget End
1995-08-31
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Bergin, C J; Sirlin, C; Deutsch, R et al. (2000) Predictors of patient response to pulmonary thromboendarterectomy. AJR Am J Roentgenol 174:509-15
Park, K J; Bergin, C J; Clausen, J L (1999) Quantitation of emphysema with three-dimensional CT densitometry: comparison with two-dimensional analysis, visual emphysema scores, and pulmonary function test results. Radiology 211:541-7
King, M A; Ysrael, M; Bergin, C J (1998) Chronic thromboembolic pulmonary hypertension: CT findings. AJR Am J Roentgenol 170:955-60
Park, K J; Bergin, C J; Harrell, J (1998) MR findings of tracheal involvement in Wegener's granulomatosis. AJR Am J Roentgenol 171:524-5
Bergin, C J (1997) Chronic thromboembolic pulmonary hypertension: the disease, the diagnosis, and the treatment. Semin Ultrasound CT MR 18:383-91
Bergin, C J; Sirlin, C B; Hauschildt, J P et al. (1997) Chronic thromboembolism: diagnosis with helical CT and MR imaging with angiographic and surgical correlation. Radiology 204:695-702
Bergin, C J; Hauschildt, J; Rios, G et al. (1997) Accuracy of MR angiography compared with radionuclide scanning in identifying the cause of pulmonary arterial hypertension. AJR Am J Roentgenol 168:1549-55
Huynh, T V; Bergin, C J; Hauschildt, J et al. (1996) Magnetic resonance detection of acute pulmonary emboli in a canine model with pathologic correlation. Acad Radiol 3:1019-24
Wolff, K; Bergin, C J; King, M A et al. (1996) Accuracy of contrast-enhanced magnetic resonance angiography in chronic thromboembolic disease. Acad Radiol 3:10-7
King, M A; Bergin, C J; Ghadishah, E et al. (1996) Detecting pulmonary abnormalities on magnetic resonance images in patients with usual interstitial pneumonitis: effect of varying window settings and gadopentetate dimeglumine. Acad Radiol 3:300-7

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