Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL052509-02
Application #
2229918
Study Section
Pathology A Study Section (PTHA)
Project Start
1995-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Roberts, Laura E; Fini, Mehdi A; Derkash, Noi et al. (2007) PD98059 enhanced insulin, cytokine, and growth factor activation of xanthine oxidoreductase in epithelial cells involves STAT3 and the glucocorticoid receptor. J Cell Biochem 101:1567-87
Seymour, Katherine J; Roberts, Laura E; Fini, Mehdi A et al. (2006) Stress activation of mammary epithelial cell xanthine oxidoreductase is mediated by p38 MAPK and CCAAT/enhancer-binding protein-beta. J Biol Chem 281:8545-58
Wright, Richard M; Ginger, Lisa A; Kosila, Noi et al. (2004) Mononuclear phagocyte xanthine oxidoreductase contributes to cytokine-induced acute lung injury. Am J Respir Cell Mol Biol 30:479-90
Wright, R M; Riley, M G; Weigel, L K et al. (2000) Activation of the human aldehyde oxidase (hAOX1) promoter by tandem cooperative Sp1/Sp3 binding sites: identification of complex architecture in the hAOX upstream DNA that includes a proximal promoter, distal activation sites, and a silencer element. DNA Cell Biol 19:459-74
McManaman, J L; Hanson, L; Neville, M C et al. (2000) Lactogenic hormones regulate xanthine oxidoreductase and beta-casein levels in mammary epithelial cells by distinct mechanisms. Arch Biochem Biophys 373:318-27
Wright, R M; McManaman, J L; Repine, J E (1999) Alcohol-induced breast cancer: a proposed mechanism. Free Radic Biol Med 26:348-54
Wright, R M; Clayton, D A; Riley, M G et al. (1999) cDNA cloning, sequencing, and characterization of male and female rat liver aldehyde oxidase (rAOX1). Differences in redox status may distinguish male and female forms of hepatic APX. J Biol Chem 274:3878-86
McManaman, J L; Neville, M C; Wright, R M (1999) Mouse mammary gland xanthine oxidoreductase: purification, characterization, and regulation. Arch Biochem Biophys 371:308-16
Terada, L S; Piermattei, D; Shibao, G N et al. (1997) Hypoxia regulates xanthine dehydrogenase activity at pre- and posttranslational levels. Arch Biochem Biophys 348:163-8
McManaman, J L; Shellman, V; Wright, R M et al. (1996) Purification of rat liver xanthine oxidase and xanthine dehydrogenase by affinity chromatography on benzamidine-sepharose. Arch Biochem Biophys 332:135-41