Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL052652-02
Application #
2230162
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1995-05-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Shimoda, Larissa A; Sham, James S K; Liu, Qiang et al. (2002) Acute and chronic hypoxic pulmonary vasoconstriction: a central role for endothelin-1? Respir Physiol Neurobiol 132:93-106
Shimoda, L A; Sylvester, J T; Booth, G M et al. (2001) Inhibition of voltage-gated K(+) currents by endothelin-1 in human pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol 281:L1115-22
Shimoda, L A; Sylvester, J T; Sham, J S (2000) Mobilization of intracellular Ca(2+) by endothelin-1 in rat intrapulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 278:L157-64
Sham, J S; Crenshaw Jr, B R; Deng, L H et al. (2000) Effects of hypoxia in porcine pulmonary arterial myocytes: roles of K(V) channel and endothelin-1. Am J Physiol Lung Cell Mol Physiol 279:L262-72
Shimoda, L A; Sham, J S; Shimoda, T H et al. (2000) L-type Ca(2+) channels, resting [Ca(2+)](i), and ET-1-induced responses in chronically hypoxic pulmonary myocytes. Am J Physiol Lung Cell Mol Physiol 279:L884-94
Shimoda, L A; Sylvester, J T; Sham, J S (1999) Chronic hypoxia alters effects of endothelin and angiotensin on K+ currents in pulmonary arterial myocytes. Am J Physiol 277:L431-9
Sham, J S; Song, L S; Chen, Y et al. (1998) Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes. Proc Natl Acad Sci U S A 95:15096-101
Song, L S; Sham, J S; Stern, M D et al. (1998) Direct measurement of SR release flux by tracking 'Ca2+ spikes' in rat cardiac myocytes. J Physiol 512 ( Pt 3):677-91
Sham, J S (1997) Ca2+ release-induced inactivation of Ca2+ current in rat ventricular myocytes: evidence for local Ca2+ signalling. J Physiol 500 ( Pt 2):285-95
Shirahata, M; Fitzgerald, R S; Sham, J S (1997) Acetylcholine increases intracellular calcium of arterial chemoreceptor cells of adult cats. J Neurophysiol 78:2388-95

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