Cgmp Regulation in the Developing Pulmonary Vasculature

Steinhorn, Robin H.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29HL054705-02
• Application #: 2233130
• Study Section: Human Embryology and Development Subcommittee 1 (HED)
• Project Start: 1995-08-01
• Project End: 1999-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: State University of New York at Buffalo
• Department: Pediatrics
• Type: Schools of Medicine
• DUNS #: 038633251
• City: Buffalo
• State: NY
• Country: United States
• Zip Code: 14260

Publications

Wedgwood, Stephen; Lakshminrusimha, Satyan; Schumacker, Paul T et al. (2015) Cyclic stretch stimulates mitochondrial reactive oxygen species and Nox4 signaling in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 309:L196-203

Heilman, Rachel P; Lagoski, Megan B; Lee, Keng Jin et al. (2015) Right ventricular cyclic nucleotide signaling is decreased in hyperoxia-induced pulmonary hypertension in neonatal mice. Am J Physiol Heart Circ Physiol 308:H1575-82

Lee, Keng Jin; Berkelhamer, Sara K; Kim, Gina A et al. (2014) Disrupted pulmonary artery cyclic guanosine monophosphate signaling in mice with hyperoxia-induced pulmonary hypertension. Am J Respir Cell Mol Biol 50:369-78

Ball, Molly K; Waypa, Gregory B; Mungai, Paul T et al. (2014) Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1?. Am J Respir Crit Care Med 189:314-24

Berkelhamer, Sara K; Mestan, Karen K; Steinhorn, Robin H (2013) Pulmonary hypertension in bronchopulmonary dysplasia. Semin Perinatol 37:124-31

Lakshminrusimha, Satyan; Steinhorn, Robin H (2013) Inodilators in nitric oxide resistant persistent pulmonary hypertension of the newborn. Pediatr Crit Care Med 14:107-9

Perez, Marta; Lakshminrusimha, Satyan; Wedgwood, Stephen et al. (2012) Hydrocortisone normalizes oxygenation and cGMP regulation in lambs with persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol 302:L595-603

Farrow, Kathryn N; Lee, Keng Jin; Perez, Marta et al. (2012) Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells. Antioxid Redox Signal 17:460-70

Wedgwood, Stephen; Lakshminrusimha, Satyan; Farrow, Kathryn N et al. (2012) Apocynin improves oxygenation and increases eNOS in persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol 302:L616-26

Wedgwood, Stephen; Lakshminrusimha, Satyan; Fukai, Tohru et al. (2011) Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension. Antioxid Redox Signal 15:1497-506