Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29HL055417-01A1
Application #
2233996
Study Section
Experimental Immunology Study Section (EI)
Project Start
1996-08-01
Project End
2001-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Cichocki, Frank; Felices, Martin; McCullar, Valarie et al. (2011) Cutting edge: microRNA-181 promotes human NK cell development by regulating Notch signaling. J Immunol 187:6171-5
Bachanova, Veronika; McCullar, Valarie; Lenvik, Todd et al. (2009) Activated notch supports development of cytokine producing NK cells which are hyporesponsive and fail to acquire NK cell effector functions. Biol Blood Marrow Transplant 15:183-94
Miller, J S; McCullar, V; Punzel, M et al. (1999) Single adult human CD34(+)/Lin-/CD38(-) progenitors give rise to natural killer cells, B-lineage cells, dendritic cells, and myeloid cells. Blood 93:96-106
Miller, J S; Cervenka, T; Lund, J et al. (1999) Purine metabolites suppress proliferation of human NK cells through a lineage-specific purine receptor. J Immunol 162:7376-82
Gaffney, P M; Lund, J; Miller, J S (1998) FLT-3 ligand and marrow stroma-derived factors promote CD3gamma, CD3delta, CD3zeta, and RAG-2 gene expression in primary human CD34+LIN-DR- marrow progenitors. Blood 91:1662-70
Miller, J S; McCullar, V; Verfaillie, C M (1998) Ex vivo culture of CD34+/Lin-/DR- cells in stroma-derived soluble factors, interleukin-3, and macrophage inflammatory protein-1alpha maintains not only myeloid but also lymphoid progenitors in a novel switch culture assay. Blood 91:4516-22
Miller, J S; Prosper, F; McCullar, V (1997) Natural killer (NK) cells are functionally abnormal and NK cell progenitors are diminished in granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cell collections. Blood 90:3098-105