Body fluid homeostasis is critically important for normal physiological function of the cardiovascular system. Recent evidence suggests that t he diagonal band of Broca (DBB) participates in the central regulation of body fluid balance. More specifically, the DBB relays information from high pressure baroreceptors to vasopressin releasing neurons in the supraoptic nucleus of the hypothalamus (SON) and influences drinking behavior. However, it has not been determined how information from peripheral baroreceptors reaches the DBB and how this input modifies the activity of the DBB neurons.
The aim of the experiments in this proposal is to determine the role of the DBB and other neural systems in the baroreceptors control of vasopressin release from the SON.
This aim will be addressed by conducting in vivo electrophysiological experiments which will examine 1) the effects of peripheral baroreceptor afferent stimulation on magnocellular supraoptic neurons, 2) the role of noradrenergic receptors within the DBB in the baroreceptor-mediated inhibition of vasopressin SON neurons, 3) the source and influence of the noradrenergic innervation of the DBB. This work will provide new information about the organization of the pathways within the central nervous system that mediate the baroreceptor regulation of body fluid homeostasis. This information may provide a model of how baroreceptor afferents regulate neuroendocrine, autonomic and behavioral systems and how this regulation is altered by the development of disease states.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29HL055692-01
Application #
2234319
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1995-06-01
Project End
1999-05-31
Budget Start
1995-06-01
Budget End
1996-05-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Missouri-Columbia
Department
Miscellaneous
Type
Other Domestic Higher Education
DUNS #
112205955
City
Columbia
State
MO
Country
United States
Zip Code
65211
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