Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29HL056712-01
Application #
2235183
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1996-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
Lin, Haocheng; Yuan, Jiuhong; Ruan, Ke-He et al. (2013) COX-2-10aa-PGIS gene therapy improves erectile function in rats after cavernous nerve injury. J Sex Med 10:1476-87
Ruan, Ke-He; Mohite, Anita; So, Shui-Ping et al. (2013) Establishing novel prostacyclin-synthesizing cells with therapeutic potential against heart diseases. Int J Cardiol 163:163-9
Chillar, Annirudha J; Karimi, Parastoo; Tang, Kathy et al. (2011) An agonist sensitive, quick and simple cell-based signaling assay for determination of ligands mimicking prostaglandin E2 or E1 activity through subtype EP1 receptor: Suitable for high throughput screening. BMC Complement Altern Med 11:11
Chillar, Annirudha; So, Shui-Ping; Ruan, Cheng-Huai et al. (2011) A profile of NSAID-targeted arachidonic acid metabolisms in human embryonic stem cells (hESCs): implication of the negative effects of NSAIDs on heart tissue regeneration. Int J Cardiol 150:253-9
Ruan, Cheng-Huai; So, Shui-Ping; Ruan, Ke-He (2011) Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: mechanisms of COX-2 inhibitor risk to heart disease. Life Sci 88:24-30
Mohite, Anita; Chillar, Annirudha; So, Shui-Ping et al. (2011) Novel mechanism of the vascular protector prostacyclin: regulating microRNA expression. Biochemistry 50:1691-9
Chillar, Annirudha; Wu, Jiaxin; Cervantes, Vanessa et al. (2010) Structural and functional analysis of the C-terminus of Galphaq in complex with the human thromboxane A2 receptor provides evidence of constitutive activity. Biochemistry 49:6365-74
Ruan, Ke-He; Cervantes, Vanessa; Wu, Jiaxin (2009) Ligand-specific conformation determines agonist activation and antagonist blockade in purified human thromboxane A2 receptor. Biochemistry 48:3157-65
Ruan, Ke-He; Cervantes, Vanessa; So, Shui-Ping (2009) Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2. Protein Eng Des Sel 22:733-40