The objective of this project is to test and refine a device to assist a surgeon in locating a target of interest as defined from pre-operative medical images. The method, an outgrowth of stereotactic surgery, combines recent advances in medical imaging, high precision position sensing, robotics and computer technology to provide the surgeon with an interactive display of the present position of a surgical instrument on the pre- operative images. Once the device has been calibrated and its accuracy defined and validated, the device can be used to: 1) guide the surgeon directly to the target point, minimizing the size of the total resection, 2) guide the surgeon to objects, such as tumor margins, which may be defined on CT or MR images but be visually indistinguishable from normal tissue, 3) guide the placement of brachytherapy radiation sources for optimum dose distribution, 4) steer laser resection and 5), guide electrode and biosensor placement. If successful, the arm should incorporate the stereotactic advantage of accurate registration of image and physical space without the requirements of present frame-based systems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29NS028602-01A1
Application #
3478073
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1991-01-01
Project End
1995-12-31
Budget Start
1991-01-01
Budget End
1991-12-31
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Lewis, J T; Galloway Jr, R L; Schreiner, S (1998) An ultrasonic approach to localization of fiducial markers for interactive, image-guided neurosurgery--Part I: Principles. IEEE Trans Biomed Eng 45:620-30
Schreiner, S; Galloway Jr, R L; Lewis, J T et al. (1998) An ultrasonic approach to localization of fiducial markers for interactive, image-guided neurosurgery--Part II: Implementation and automation. IEEE Trans Biomed Eng 45:631-41
Schreiner, S; Paschal, C B; Galloway, R L (1996) Comparison of projection algorithms used for the construction of maximum intensity projection images. J Comput Assist Tomogr 20:56-67
Galloway Jr, R L; Maciunas, R J; Edwards 2nd, C A (1992) Interactive image-guided neurosurgery. IEEE Trans Biomed Eng 39:1226-31