Ionizing Radiation Mutagenesis in Ataxia Telangiectasia

Sikpi, Matthew O.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29NS032066-03
• Application #: 2270040
• Study Section: Radiation Study Section (RAD)
• Project Start: 1994-04-01
• Project End: 1999-01-31
• Budget Start: 1996-02-01
• Budget End: 1997-01-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: University of Connecticut
• Department: Dentistry
• Type: Schools of Dentistry
• City: Farmington
• State: CT
• Country: United States
• Zip Code: 06030

Publications

Sikpi, M O; Wang, Y (2000) Ionizing radiation enhances double-strand-break repair in rapamycin-treated ataxia telangiectasia lymphoblasts. Int J Radiat Biol 76:177-87

Wang, Y; Mallya, S M; Sikpi, M O (2000) Calmodulin antagonists and cAMP inhibit ionizing-radiation-enhancement of double-strand-break repair in human cells. Mutat Res 460:29-39

Mallya, S M; Sikpi, M O (1999) Requirement for p53 in ionizing-radiation-inhibition of double-strand-break rejoining by human lymphoblasts. Mutat Res 434:119-32

Sikpi, M O; Wang, Y; Mallya, S M (1999) Heightened induction of c-jun mRNA by PMA, EGF and IL-1 in ataxia telangiectasia lymphoblasts. Int J Radiat Biol 75:893-901

Mallya, S M; Sikpi, M O (1998) Evidence of the involvement of p53 in gamma-radiation-induced DNA repair in human lymphoblasts. Int J Radiat Biol 74:231-8

Sikpi, M O; Wang, Y; Mallya, S M (1998) Defective modulation of double-strand break repair in ataxia telangiectasia cells by gamma radiation. Radiat Res 150:627-35