Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29NS037336-01
Application #
2562021
Study Section
Special Emphasis Panel (ZRG1-NLS-3 (01))
Program Officer
Kerza-Kwiatecki, a P
Project Start
1998-02-01
Project End
1998-08-31
Budget Start
1998-02-01
Budget End
1998-08-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Trifilo, Matthew J; Montalto-Morrison, Cynthia; Stiles, Linda N et al. (2004) CXC chemokine ligand 10 controls viral infection in the central nervous system: evidence for a role in innate immune response through recruitment and activation of natural killer cells. J Virol 78:585-94
Trifilo, Matthew J; Bergmann, Cornelia C; Kuziel, William A et al. (2003) CC chemokine ligand 3 (CCL3) regulates CD8(+)-T-cell effector function and migration following viral infection. J Virol 77:4004-14
Glass, William G; Lane, Thomas E (2003) Functional analysis of the CC chemokine receptor 5 (CCR5) on virus-specific CD8+ T cells following coronavirus infection of the central nervous system. Virology 312:407-14
Glass, William G; Chen, Benjamin P; Liu, Michael T et al. (2002) Mouse hepatitis virus infection of the central nervous system: chemokine-mediated regulation of host defense and disease. Viral Immunol 15:261-72
Chen, Benjamin P; Lane, Thomas E (2002) Lack of nitric oxide synthase type 2 (NOS2) results in reduced neuronal apoptosis and mortality following mouse hepatitis virus infection of the central nervous system. J Neurovirol 8:58-63
Dufour, Jennifer H; Dziejman, Michelle; Liu, Michael T et al. (2002) IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol 168:3195-204
Liu, M T; Armstrong, D; Hamilton, T A et al. (2001) Expression of Mig (monokine induced by interferon-gamma) is important in T lymphocyte recruitment and host defense following viral infection of the central nervous system. J Immunol 166:1790-5
Liu, M T; Lane, T E (2001) Chemokine expression and viral infection of the central nervous system: regulation of host defense and neuropathology. Immunol Res 24:111-9
Kakimi, K; Lane, T E; Chisari, F V et al. (2001) Cutting edge: Inhibition of hepatitis B virus replication by activated NK T cells does not require inflammatory cell recruitment to the liver. J Immunol 167:6701-5
Liu, M T; Keirstead, H S; Lane, T E (2001) Neutralization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosis. J Immunol 167:4091-7

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