Contact Program Director/Principal Investigator: E L K I N G T O N , Paul T 2a. PROGRAM DIRECTOR / PRINCIPAL INVESTIGATOR (Name and address, street, city, state, zip code) Jeanine M D'Armiento Columbia University 630 West 168* St New York 10032-3702 2e. TELEPHONE AND FAX (Area code, number and extension) TEL: 212-305-3745 2a. PROGRAM DIRECTOR / PRINCIPAL INVESTIGATOR (Name and address, street, city, state, zip code) Suwan Jayasinghe University College London Torrington Place London WC1E7JE 2e. TELEPHONE AND FAX (Area code, number and extension) TEL: +44 (0)2076792960 f"""""""" '. 2a. PROGRAM DIRECTOR / PRINCIPAL INVESTIGATOR (Name and address, street, city, state, zip code) Miles Carroll Head of Research Health Protection Agency Porton Down Salisbury SP4 OJG 2e. TELEPHONE AND FAX (Area code, number and extension) TEL: 44 (0)1980 612340 2a. PROGRAM DIRECTOR / PRINCIPAL INVESTIGATOR (Name and address, street, city, state, zip code) |, 2e. TELEPHONE AND FAX (Area code, number and extension) TEL; 2b. E-MAIL ADDRESS jmd12@cumc.columbia.edu 2c. DEPARTMENT, SERVICE, LABORATORY, OR EQUIVALENT Department of Medicine 2d. MAJOR SUBDIVISION FAX: 2b. E-MAIL ADDRESS ' s.jayasinghe@ucl.ac.uk 2c. DEPARTMENT, SERVICE, LABORATORY, OR EQUIVALENT Engineering 2d. MAJOR SUBDIVISION FAX: 2b. E-MAIL ADDRESS Miles.Carroll@hpa.org.uk 2c. DEPARTMENT, SERVICE, LABORATORY, OR EQUIVALENT Microbiology Services Division 2d. MAJOR SUBDIVISION FAX; 2b. E-MAIL ADDRESS ' 2c. DEPARTMENT, SERVICE, LABORATORY, OR EQUIVALENT 2d. MAJOR SUBDIVISION FAX: PHS 2590 (Rev. 08/12) Face Page-continued Form Page 1-Continued Program Director/Principal Investigator (Last, First, Middle);E L K I N G T O N P a u l T DETAILED BUDGET FOR NEXT BUDGET FROIVI THROUGH GRANT NUMBER PERIOD - DIRECT COSTS ONLY 07/01/2014 06/30/2015 R21 Al 102239-01 List PERSONNEL (Applicant organization only) Use Cal, Acad, or Summer to Enter Months Devoted to Project NAME ROLE ON PROJECT ELKINGTON, Paul PD/PI TEZERA, Liku Post-doc SUBTOTALS CONSULTANT COSTS EQUIPMENT (Itemize) Cal. Acad. Summer SALARY FRINGE Mnths Mnths Mnths REQUESTED BENEFITS TOTALS 0.70 9,727 9,727 12 72,499 72,499 82,226 82,226 SUPPLIES (Itemize by category) Laboratory consumables and disposables for the containment level 3 tuberculosis laboratory 35,214 TRAVEL Foreign Travel 3,900 INPATIENT CARE COSTS OUTPATIENT CARE COSTS ALTERATIONS AND RENOVATIONS (Itemize by category) OTHER EXPENSES (Itemize by category) Animal costs 47,529 SUBTOTAL DIRECT COSTS FOR NEXT BUDGET PERIOD 168,869 CONSORTIUM/CONTRACTUAL COSTS DIRECT COSTS 131,025 CONSORTIUM/CONTRACTUAL COSTS FACILITIES AND ADMINISTRATIVE COSTS 75,482 TOTAL DIRECT COSTS FOR NEXT BUDGET PERIOD (Item 8a, Face Page) $ 299,894 PHS 2590 (Rev. 08/12) Page, Form Page 2

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants Phase II (R33)
Project #
4R33AI102239-03
Application #
8856692
Study Section
No Study Section (in-house review) (NSS)
Program Officer
Lacourciere, Karen A
Project Start
2012-07-01
Project End
2017-06-30
Budget Start
2014-07-18
Budget End
2015-06-30
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Southampton
Department
Type
DUNS #
City
Southampton
State
Country
United Kingdom
Zip Code
SO17 1BJ
Tezera, Liku B; Bielecka, Magdalena K; Elkington, Paul T (2017) Bioelectrospray Methodology for Dissection of the Host-pathogen Interaction in Human Tuberculosis. Bio Protoc 7:
Walker, Naomi F; Wilkinson, Katalin A; Meintjes, Graeme et al. (2017) Matrix Degradation in Human Immunodeficiency Virus Type 1-Associated Tuberculosis and Tuberculosis Immune Reconstitution Inflammatory Syndrome: A Prospective Observational Study. Clin Infect Dis 65:121-132
Brace, Patience T; Tezera, Liku B; Bielecka, Magdalena K et al. (2017) Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology. PLoS Pathog 13:e1006367
Chancellor, Andrew; Tocheva, Anna S; Cave-Ayland, Chris et al. (2017) CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains. Proc Natl Acad Sci U S A 114:E10956-E10964
Bielecka, Magdalena K; Tezera, Liku B; Zmijan, Robert et al. (2017) A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis. MBio 8:
Tezera, Liku B; Bielecka, Magdalena K; Chancellor, Andrew et al. (2017) Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model. Elife 6:
Kubler, Andre; Larsson, Christer; Luna, Brian et al. (2016) Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis. J Infect Dis 213:618-27
Elkington, Paul; Tebruegge, Marc; Mansour, Salah (2016) Tuberculosis: An Infection-Initiated Autoimmune Disease? Trends Immunol 37:815-818
Elkington, Paul; Zumla, Alimuddin (2015) Update in Mycobacterium tuberculosis lung disease 2014. Am J Respir Crit Care Med 192:793-8
Al Shammari, Basim; Shiomi, Takayuki; Tezera, Liku et al. (2015) The Extracellular Matrix Regulates Granuloma Necrosis in Tuberculosis. J Infect Dis 212:463-73

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