Catheter Scope for Intraluminal Imaging of Early Neoplasia A micro-optical scanner has been demonstrated to efficiently transmit high-quality laser illumination at high resolution across a wide and variable field-of-view. The scanner is a microfabricated optical fiber that is driven in vibratory resonance. Since the laser light is scanned, images are acquired one pixel at a time, and most importantly, only a single optical fiber is required for illumination. This single optical fiber and a few collection fibers (either optical fibers or electrical wires from optical detectors) can be contained in an ultrathin catheter-style package of less than 2.5 mm in diameter. Therefore, high quality images can be obtained in regions of the body that were previously inaccessible. We propose to fabricate, test, and develop a proof-of-concept catheter scope in the first year (R21 phase), and then to build and test in vivo more advanced prototypes in the subsequent 3 years (R33 phase). The ultrathin catheter scope will be designed to fit within the 2.8 mm diameter working channel of a standard GI endoscope or standard flexible bronchoscope. Immediate goals are to determine feasibility of using this new in vivo imaging technology for the early detection of cancer in the pancreas and peripheral lung. The unique features of the prototype catheter scope are its high flexibility, small diameter, variable resolution imaging, enhanced depth perception using stereo-pair detectors, and enhanced image contrast using laser-induced fluorescence, and polarization contrast of the epithelial tissue layers. The long-term goals are to bring laser scanning endoscopy and bronchoscopy to the forefront of minimally-invasive medical practice, as a tool to image remote locations in the body, screen and diagnose for early detection of cancer, and in the future deliver optical therapies with pixel accuracy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory/Developmental Grants Phase II (R33)
Project #
4R33CA094303-02
Application #
6943312
Study Section
Special Emphasis Panel (ZCA1-SRRB-9 (J2))
Program Officer
Baker, Houston
Project Start
2003-07-23
Project End
2007-08-31
Budget Start
2004-09-10
Budget End
2005-08-31
Support Year
2
Fiscal Year
2004
Total Cost
$557,608
Indirect Cost
Name
University of Washington
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Shah, Jyotsna; Poruri, Akhila; Mark, Olivia et al. (2017) A dual colour fluorescence in situ hybridization (FISH) assay for identifying the zoonotic malaria parasite Plasmodium knowlesi with a potential application for the specific diagnosis of knowlesi malaria in peripheral-level laboratories of Southeast Asia. Parasit Vectors 10:342
Pershing, Suzann; Enns, Eva A; Matesic, Brian et al. (2014) Cost-effectiveness of treatment of diabetic macular edema. Ann Intern Med 160:18-29
Yoon, W Jong; Brown, Matthew A; Reinhall, Per G et al. (2012) Design and preliminary study of custom laser scanning cystoscope for automated bladder surveillance. Minim Invasive Ther Allied Technol 21:320-8
Saar, Brian G; Johnston, Richard S; Freudiger, Christian W et al. (2011) Coherent Raman scanning fiber endoscopy. Opt Lett 36:2396-8
Kundrat, Matthew J; Reinhall, Per G; Lee, Cameron M et al. (2011) High Performance Open Loop Control of Scanning with a Small Cylindrical Cantilever Beam. J Sound Vib 330:1762-1771
Seibel, Eric J; Brentnall, Teresa A; Dominitz, Jason A (2009) New endoscopic and cytologic tools for cancer surveillance in the digestive tract. Gastrointest Endosc Clin N Am 19:299-307
Yoon, W Jong; Park, Sangtae; Reinhall, Per G et al. (2009) Development of an Automated Steering Mechanism for Bladder Urothelium Surveillance. J Med Device 3:11004
Seibel, Eric J; Brown, Christopher M; Dominitz, Jason A et al. (2008) Scanning single fiber endoscopy: a new platform technology for integrated laser imaging, diagnosis, and future therapies. Gastrointest Endosc Clin N Am 18:467-78, viii