? Preliminary studies utilizing optical coherence tomography (OCT) have demonstrated that this high-resolution imaging modality can facilitate the accurate diagnosis of a variety of diseases, including coronary atherosclerosis and cancer. Presently, the image acquisition rate of state-of-the-art OCT technology is limited to a few frames per second and therefore micro-structural diagnostic information can only be obtained at discrete locations. The potential diagnostic applications having the highest impact, however, require screening or surveillance of large tissue volumes. Since the current technology commonly operates at its theoretical limit of detection sensitivity, dramatic improvements in imaging speed can only be obtained through a fundamental technological paradigm shift. ? We propose to develop a new optical tomographic imaging method based on optical frequency domain reflectometry. Our preliminary studies show that optical frequency-domain imaging (OFDI) technology can offer several-hundred-fold higher sensitivity and more than ten-fold faster imaging speed than the existing OCT technology. The objective of this research is to develop and validate OFDI for high-speed, high-sensitivity, in vivo clinical imaging. The design of the proposed technology is tailored to two high-impact clinical goals: comprehensive surveillance for esophageal neoplasia in patients with Barrett's esophagus and characterization of vulnerable coronary plaques responsible for acute myocardial infarction. Two clinical pilot studies, using technology developed in this work, will be conducted to test system performance relevant to achieving these goals. ? ?
| Kang, Jeon Woong; Kim, Pilhan; Alonzo, Carlo Amadeo et al. (2010) Two-photon microscopy by wavelength-swept pulses delivered through single-mode fiber. Opt Lett 35:181-3 |
| Kim, Pilhan; Chung, Euiheon; Yamashita, Hiroshi et al. (2010) In vivo wide-area cellular imaging by side-view endomicroscopy. Nat Methods 7:303-5 |
| Desjardins, Adrien E; Vakoc, Benjamin J; Suter, Melissa J et al. (2009) Real-time FPGA processing for high-speed optical frequency domain imaging. IEEE Trans Med Imaging 28:1468-72 |
| Bouma, Brett E; Yun, Seok-Hyun; Vakoc, Benjamin J et al. (2009) Fourier-domain optical coherence tomography: recent advances toward clinical utility. Curr Opin Biotechnol 20:111-8 |
| Zhong, W; Celli, J P; Rizvi, I et al. (2009) In vivo high-resolution fluorescence microendoscopy for ovarian cancer detection and treatment monitoring. Br J Cancer 101:2015-22 |
| Scarcelli, Giuliano; Yun, Seok H (2008) Entangled-photon coincidence fluorescence imaging. Opt Express 16:16189-94 |
| Oh, W Y; Yun, S H; Vakoc, B J et al. (2008) High-speed polarization sensitive optical frequency domain imaging with frequency multiplexing. Opt Express 16:1096-103 |
| Scarcelli, Giuliano; Kim, Pilhan; Yun, Seok Hyun (2008) Cross-axis cascading of spectral dispersion. Opt Lett 33:2979-81 |
| Sharma, Utkarsh; Chang, Ernest W; Yun, Seok H (2008) Long-wavelength optical coherence tomography at 1.7 microm for enhanced imaging depth. Opt Express 16:19712-23 |
| Vakoc, Benjamin J; Shishko, Milen; Yun, Seok H et al. (2007) Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video). Gastrointest Endosc 65:898-905 |
Showing the most recent 10 out of 14 publications
