FMRI has become a tool for mapping brain function because of its high spatial and temporal resolution and noninvasiveness. In addition, it is applicable to single subjects and thus could play a role in the clinical realm. These properties are appealing for use in clinical populations, for research, treatment and disease monitoring. However, in contrast to normal volunteers, clinical populations are more likely to move, more likely to fail to conform to the task and are less tolerant to long imaging sessions. Thus, these subjects may generate less data and of lower quality than normal making it more difficult to detect the low signal changes inherent in BOLD contrast fMRI. In addition, qualified patients are more difficult to come by than normal making it critical to insure that useful data has been acquired. Timely feedback from results is also necessary for treatment planning. Thus, we have set out to develop a clinical competent fMRI system that is more flexible and more efficient that existing systems. The goal of the system is to provide time efficient estimation of activation in the presence of multiple concurrent effects, track processes that lead to confounding effects (motion, speech, cardiac pulsatility, respiration, etc) and adapt the processing to the subject's performance rather than the expected task. Major components of this system such as the timeaware architecture, measurement and filtering of physiologic data (speech, cardiac, respiration, skin conductance) and real-time multiple linear regression have been completed. We will extend the system by incorporatingdetection of and correction for motion, modeling of physiologic noise and development of real-time speech detection for use in a paradigm where both the timing of paradigm delivery and processing of the data is driven by the subject's response.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Exploratory/Developmental Grants Phase II (R33)
Project #
5R33EB001484-02
Application #
6710642
Study Section
Special Emphasis Panel (ZCA1-SRRB-9 (O1))
Program Officer
Mclaughlin, Alan Charles
Project Start
2003-03-01
Project End
2006-02-28
Budget Start
2004-03-01
Budget End
2005-02-28
Support Year
2
Fiscal Year
2004
Total Cost
$318,728
Indirect Cost
Name
University of Iowa
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
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Grabowski, Thomas J; Bauer, Matthew D; Foreman, Derek et al. (2006) Adaptive pacing of visual stimulation for fMRI studies involving overt speech. Neuroimage 29:1023-30