Alcohol use disorders (AUDs) are the 3rd leading preventable cause of death in the U.S. and are associated with significant economic burden and health-related negative consequences. While women may be less likely to develop AUDs, they experience more significant negative health consequences of alcohol use than men. Due to stigma, shame, and child care issues; women are less likely to receive specialty addiction treatment. The comorbidity of depression and AUDs is much higher in women, and compared to men, women depression often has a temporal onset prior to an AUD. Relapse rates are very high in both men and women but significant gender differences emerge in the predictors of relapse. Women are more likely to relapse in unpleasant, negative emotional states and depressive symptoms and negative affect mediate the relationship between these stressors and drinking outcomes. More so than men, women with AUDs report drinking to cope with negative emotions. Therefore, intervention approaches that help women develop alternate coping strategies can have an important role in decreasing alcohol relapse among depressed women with AUDs. Given the demonstrated benefits of exercise for decreasing depression, negative affect, and urges to drink, helping women engage in a flexible and acceptable lifestyle physical activity (LPA) intervention may provide them a tool they can utilizing in the moment to cope with negative emotional states and alcohol craving during early recovery when relapse risk is highest. Exciting new digital fitness technologies (e.g., Fitbit activity monitor with web and mobile applications) have emerged in recent years that include features able to further enhance critical components for increasing physical activity - goal setting and self-monitoring. We propose to develop a 12-week LPA+Fitbit intervention for depressed women in alcohol treatment. This will include: 1) an in-person physical activity (PA) counseling orientation session 2) 4 brief, phone-based PA counseling sessions focused on increasing PA and strategically using bouts of PA to cope with affect and alcohol cravings; 3) use of the Fitbit fitness tracker fo physical activity goal-setting and daily self-monitoring; and 4) weekly supportive messages delivered by email. The overall objective of this application is to develop this LPA+Fitbit intervention, modify it based on a initial open pilot (n=20) and feedback to ensure its feasibility and acceptability for depressed women with AUDs in early recovery, propose potential mechanisms, and to obtain preliminary data on its efficacy in a small randomized clinical trial (n=50). The LPA+Fitbit intervention proposed in this application is simple, low-cost, and easily transportable to the varied clinical settings women with AUDs receive treatment. If women with AUDs find the LPA+Fitbit intervention feasible, acceptable, and helpful during early recovery, they could be afforded with a much needed alternate coping strategy that would reduce relapse risk and decrease the overall negative impact of alcohol use on their health and well-being.

Public Health Relevance

We expect that as a result of this project will lead to the development of a well-specified, novel physical activity intervention, the efficacy of which can be tested in future randomized clinical trials. Furthermore, this project will contribute much-needed knowledge about the role of physical activity in reducing alcohol use, decreasing depressive symptoms and negative mood, and increasing fitness in alcohol dependent women. If the efficacy of the LPA+Fitbit intervention can be established, depressed women with Alcohol Use Disorders (AUDs) will be provided with a valuable adjunct to traditional alcohol treatment that can be delivered across varied treatment settings thereby decreasing their overall risk for the negative effects of AUDs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Planning Grant (R34)
Project #
5R34AA024038-02
Application #
9145615
Study Section
Neuroscience Review Subcommittee (AA)
Program Officer
Roach, Deidra
Project Start
2015-09-20
Project End
2018-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Butler Hospital (Providence, RI)
Department
Type
DUNS #
069847804
City
Providence
State
RI
Country
United States
Zip Code
Abrantes, Ana M; Blevins, Claire E; Battle, Cynthia L et al. (2017) Developing a Fitbit-supported lifestyle physical activity intervention for depressed alcohol dependent women. J Subst Abuse Treat 80:88-97
Blevins, Claire E; Rapoport, Marie A; Battle, Cynthia L et al. (2017) Changes in Coping, Autonomous Motivation, and Beliefs about Exercise among Women in Early Recovery from Alcohol Participating in a Lifestyle Physical Activity Intervention. Ment Health Phys Act 13:137-142