The proposed research has the following goals: 1) Develop and standardize a manual-based individual therapy for first-episode (FE) schizophrenia that is sensitive to the early stages of recovery from initial psychosis (i.e., the """"""""Graduated Recovery Intervention Program;"""""""" GRIP); 2) Pilot test GRIP in a small-scale randomized controlled trial (RCT) to obtain specific intervention parameters, including effect sizes and attrition rates, as well as preliminary efficacy data; and 3) Collect preliminary data on intervention moderators and mediators. To achieve these goals, we will conduct the proposed research in three stages. During the first stage, we will refine and standardize the GRIP manual. In the second stage, we will conduct an open, uncontrolled pilot test of the intervention on 6 patients. Following the open trial, we will develop a final version of the GRIP manual. In the third phase of the research, we will conduct a small pilot randomized controlled trial of GRIP (n=25) versus supportive counseling (SC; n=25) for individuals with FE schizophrenia spectrum disorders (i.e., schizophrenia; schizoaffective disorder; schizophreniform disorder). Participants will be assessed at baseline, mid-treatment, post-treatment, and three-month follow-up on a variety of outcome measures, including social functioning, substance use, medication attitudes and adherence, rehospitalization, and symptoms.
| Uzenoff, Sarah R; Penn, David L; Graham, Karen A et al. (2012) Evaluation of a multi-element treatment center for early psychosis in the United States. Soc Psychiatry Psychiatr Epidemiol 47:1607-15 |
| Penn, David L; Uzenoff, Sarah R; Perkins, Diana et al. (2011) A pilot investigation of the Graduated Recovery Intervention Program (GRIP) for first episode psychosis. Schizophr Res 125:247-56 |
| Uzenoff, Sarah R; Brewer, Katherine C; Perkins, Diana O et al. (2010) Psychological well-being among individuals with first-episode psychosis. Early Interv Psychiatry 4:174-81 |
| Penn, David L; Keefe, Richard S E; Davis, Sonia M et al. (2009) The effects of antipsychotic medications on emotion perception in patients with chronic schizophrenia in the CATIE trial. Schizophr Res 115:17-23 |
| Waldheter, Evan J; Penn, David L; Perkins, Diana O et al. (2008) The graduated recovery intervention program for first episode psychosis: treatment development and preliminary data. Community Ment Health J 44:443-55 |
