Abstract

This grant will be utilized to support the clinical therapeutic research efforts of Dr. Freireich. His major research activities relate to bridging between laboratories and clinical science. The fundamental observations of therapeutic effects in patients with adult acute leukemia reveal important new investigative opportunities for the laboratory scientist and at the same time, progress in basic laboratory research has the potential for leading to new fundamental understanding of the clinical diseases. Dr. Freireich's career commitment to the understanding of acute leukemia has contributed significantly to the rapid revealed important new biological facts about disseminated leukemia which have found wide application to the understanding of cancer biology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA039809-05
Application #
3479078
Study Section
(SRC)
Project Start
1985-08-15
Project End
1992-07-31
Budget Start
1989-08-01
Budget End
1990-07-31
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Type
Hospitals
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Andersson, B S; Collins, V P; Kurzrock, R et al. (1995) KBM-7, a human myeloid leukemia cell line with double Philadelphia chromosomes lacking normal c-ABL and BCR transcripts. Leukemia 9:2100-8
O'Brien, S; Kantarjian, H; Freireich, E et al. (1992) CI-973, a new platinum derivative with potential antileukemic activity. Cancer Res 52:4130-4
Chang, K S; Lu, J F; Wang, G et al. (1992) The t(15;17) breakpoint in acute promyelocytic leukemia cluster within two different sites of the myl gene: targets for the detection of minimal residual disease by the polymerase chain reaction. Blood 79:554-8
Freireich, E J; Cork, A; Stass, S A et al. (1992) Cytogenetics for detection of minimal residual disease in acute myeloblastic leukemia. Leukemia 6:500-6
Andersson, B S; Bergerheim, U S; Collins, V P et al. (1992) KBM-3, an in vitro model of human acute myelomonocytic leukemia. Exp Hematol 20:361-7
Chang, K S; Wang, G; Freireich, E J et al. (1992) Specific expression of the annexin VIII gene in acute promyelocytic leukemia. Blood 79:1802-10
Chang, K S; Stass, S A; Chu, D T et al. (1992) Characterization of a fusion cDNA (RARA/myl) transcribed from the t(15;17) translocation breakpoint in acute promyelocytic leukemia. Mol Cell Biol 12:800-10
Chang, K S; Trujillo, J M; Ogura, T et al. (1991) Rearrangement of the retinoic acid receptor gene in acute promyelocytic leukemia. Leukemia 5:200-4
Zwelling, L A; Mayes, J; Hinds, M et al. (1991) Cross-resistance of an amsacrine-resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence for two topoisomerase II directed drug actions. Biochemistry 30:4048-55
Chang, K S; Zhao, S R; Wang, Y P et al. (1991) Down regulation of myeloperoxidase gene associated with specific nuclease hypersensitive sites during TPA induced differentiation of HL-60. Leukemia 5:205-9

Showing the most recent 10 out of 28 publications