Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
3R35CA042504-03S1
Application #
3479298
Study Section
(SRC)
Project Start
1986-06-01
Project End
1993-06-30
Budget Start
1988-06-01
Budget End
1989-06-30
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Eisen, H N; Sykulev, Y; Tsomides, T J (1996) Antigen-specific T-cell receptors and their reactions with complexes formed by peptides with major histocompatibility complex proteins. Adv Protein Chem 49:1-56
Sykulev, Y; Cohen, R J; Eisen, H N (1995) The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes. Proc Natl Acad Sci U S A 92:11990-2
Kageyama, S; Tsomides, T J; Sykulev, Y et al. (1995) Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses. J Immunol 154:567-76
Wu, M X; Tsomides, T J; Eisen, H N (1995) Tissue distribution of natural peptides derived from a ubiquitous dehydrogenase, including a novel liver-specific peptide that demonstrates the pronounced specificity of low affinity T cell reactions. J Immunol 154:4495-502
Sykulev, Y; Brunmark, A; Jackson, M et al. (1994) Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes. Immunity 1:15-22
Dutz, J P; Tsomides, T J; Kageyama, S et al. (1994) A cytotoxic T lymphocyte clone can recognize the same naturally occurring self peptide in association with a self and nonself class I MHC protein. Mol Immunol 31:967-75
Tsomides, T J; Aldovini, A; Johnson, R P et al. (1994) Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. J Exp Med 180:1283-93
Dutz, J P; Fruman, D A; Burakoff, S J et al. (1993) A role for calcineurin in degranulation of murine cytotoxic T lymphocytes. J Immunol 150:2591-8
Tsomides, T J; Eisen, H N (1993) Stoichiometric labeling of peptides by iodination on tyrosyl or histidyl residues. Anal Biochem 210:129-35
Su, M W; Walden, P R; Golan, D B et al. (1993) Cognate peptide-induced destruction of CD8+ cytotoxic T lymphocytes is due to fratricide. J Immunol 151:658-67

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