1. Lymphocyte differentiation antigens: gene cloning, regulation and function 2. Immunoglobulin genetics, structure and function 3. B and T cell subset definitions, development, lineages and functions 4. Development of fluorescence activated cell sorting Overall, we hope to understand the molecules and cells of the immune system: how they develop, interact, are regulated, function, and result in immune disorders and malignancies when they malfunction. Novel interspecific chimeric antibodies and site-specific mutated antibodies will be explored for reduced immunogenecity for use as therapeutic agents and for structure/function understanding.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA042509-07
Application #
3479345
Study Section
Special Emphasis Panel (SRC)
Project Start
1986-07-01
Project End
1993-06-30
Budget Start
1992-07-24
Budget End
1993-06-30
Support Year
7
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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