Abstract

Acquisition of a helium recovery system for Nuclear Magnetic Resonance (NMR) and Ion Cyclotron Resonance Mass (ICR-MS) Spectrometers The R35 research program Chemical Synthesis of Complex Natural Products for Translation Science (R35GM118173) is focused on the chemical synthesis of important classes of bioactive molecules and their application in translational collaborations. A supplement to purchase a helium recovery system for two NMRs and one ICR-MS will greatly reduce the purchase of liquid helium which as PA-18-591 demonstrated will become increasingly more costly and more difficult to have adequate supplies beginning in 2020. The 400 and 500 MHz NMR systems and the FT-ICR liquid chromatography mass spectrometer not only are critical to the success of the R35GM118173 MIRA program but are also routine and key characterization techniques for six other NIGMS funded groups at BU (Elliott, Grinstaff, Reinhard, Schaus, Vegas, and Whitty). A helium recovery system is requested from Quantum Design, Inc. ($249,550) to provide a closed loop system where helium is captured, re-liquefied and refilled to each of the cyro magnets. The requested instrument will fill a critical helium recovery need in the Chemical Instrumentation Center (CIC) and the Department of Chemistry where those magnets are sited.

Public Health Relevance

Acquisition of a helium recovery system for Nuclear Magnetic Resonance (NMR) and Ion Cyclotron Resonance Mass (ICR-MS) Spectrometers An administrative supplement for an Advanced Technology Liquefier and Medium Pressure Helium Recovery System is requested in response to (PA-18-591) to use in conjunction with NMR and ICR-MS spectrometers and serve and optimize the project?s liquid helium needs. The Advanced Technology Liquefier (ATL) - Medium Pressure Helium Recovery system will be used to recover the helium boil off from three heavily used spectrometer magnets. The increasing shortage of liquid helium is resulting in both infrequent supplies and regular price hikes. The ATL-Helium recovery system will help reduce the project?s dependency on commercial liquid helium and will also ensure the stability of the project?s future cryogenic needs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Unknown (R35)
Project #
3R35GM118173-04S1
Application #
9989397
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Bond, Michelle Rueffer
Project Start
2016-05-01
Project End
2021-04-30
Budget Start
2019-05-01
Budget End
2020-04-30
Support Year
4
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
Boston University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
049435266
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Wu, Xiaowei; Iwata, Takayuki; Scharf, Adam et al. (2018) Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling. J Am Chem Soc 140:5969-5975
Qi, Chao; Wang, Wenyu; Reichl, Kyle D et al. (2018) Total Synthesis of Aurofusarin: Studies on the Atropisomeric Stability of Bis-Naphthoquinones. Angew Chem Int Ed Engl 57:2101-2104
Langlais, David; Cencic, Regina; Moradin, Neda et al. (2018) Rocaglates as dual-targeting agents for experimental cerebral malaria. Proc Natl Acad Sci U S A 115:E2366-E2375
Smith, Michael J; Reichl, Kyle D; Escobar, Randolph A et al. (2018) Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition. J Am Chem Soc :
Zhang, Wenhan; Liu, Shufeng; Maiga, Rayelle I et al. (2018) Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for HCV Infection. J Am Chem Soc :
Qin, Xu-Jie; Feng, Mi-Yan; Liu, Hui et al. (2018) Eucalyptusdimers A-C, Dimeric Phloroglucinol-Phellandrene Meroterpenoids from Eucalyptus robusta. Org Lett 20:5066-5070
Yueh, Han; Gao, Qiwen; Porco Jr, John A et al. (2017) A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues. Bioorg Med Chem 25:6197-6202
Reichl, Kyle D; Smith, Michael J; Song, Min K et al. (2017) Biomimetic Total Synthesis of (±)-Griffipavixanthone via a Cationic Cycloaddition-Cyclization Cascade. J Am Chem Soc 139:14053-14056
Wang, Wenyu; Clay, Anthony; Krishnan, Retheesh et al. (2017) Total Syntheses of the Isomeric Aglain Natural Products Foveoglin?A and Perviridisin?B: Selective Excited-State Intramolecular Proton-Transfer Photocycloaddition. Angew Chem Int Ed Engl 56:14479-14482
Manier, Salomon; Huynh, Daisy; Shen, Yu J et al. (2017) Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med 9:

Showing the most recent 10 out of 14 publications