Oxylipins are fatty acid derivatives that play an important role in inflammation ? serving as pro-inflammatory, anti-inflammatory, and/or pro-resolving signals depending on the compound and the context. This proposal will investigate how oxylipin signaling occurs between cell types to better understand oxylipin mechanisms in normal physiology and diseases with deregulated inflammation (such as asthma, infection, benign hyperplasia, and cancer). We will develop a suite of microfluidic tools to broaden the scope of mechanistic questions that can be addressed, ultimately enabling the development of therapies to target dysfunctional signaling in human disease.
