A myriad of Central Nervous System (CNS) anomalies have been identified in abstinent alcoholic patients. These deficits have been observed with the use of various techniques such as computerized axial tomography (CAT), Magnetic Resonance Imaging (MRI), Evoked Brain Potentials (EBP), Electroencephalography (EEG) and Neuropsychological tests (NP). Until recently, the aforementioned CNS deficits observed in alcoholics have been interpreted to reflect the deleterions effects of alcohol abuse. Neurophysiological studies now indicate that some of the deficits noted in abstinent alcoholics are also present in young sons of alcoholics not exposed to alcohol. Furthermore, recent evidence indicates that alcoholism is not a homogeneous disease. The presence or absence of a family history of alcoholism alone does not account for the clinically disparate subgroups of alcoholics. Thus there is evidence for both clinical and genetic heterogeneity in alcoholism. We propose to conduct several neurophysiological (EBP and EEG) studies in different homogeneous subgroups of abstinent alcoholics classified according to specific clinical as well as genetic (family history) variables. Moreover, the clinical subgroups (Type 1 -Type 2) will also be assessed for the presence or absence of specific heritable personality traits. The proposed studies should provide significant data on etiological factors involved in alcoholism.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AA002686-15
Application #
3479850
Study Section
Special Emphasis Panel (SRCA (80))
Project Start
1979-08-01
Project End
1993-02-28
Budget Start
1991-03-01
Budget End
1992-02-29
Support Year
15
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Suny Downstate Medical Center
Department
Type
Schools of Medicine
DUNS #
068552207
City
Brooklyn
State
NY
Country
United States
Zip Code
11203
Pandey, Ashwini K; Kamarajan, Chella; Rangaswamy, Madhavi et al. (2012) Event-Related Oscillations in Alcoholism Research: A Review. J Addict Res Ther Suppl 7:
Kamarajan, Chella; Rangaswamy, Madhavi; Manz, Niklas et al. (2012) Topography, power, and current source density of ? oscillations during reward processing as markers for alcohol dependence. Hum Brain Mapp 33:1019-39
Kamarajan, Chella; Rangaswamy, Madhavi; Tang, Yongqiang et al. (2010) Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task. J Psychiatr Res 44:576-90
Chorlian, David Balin; Rangaswamy, Madhavi; Porjesz, Bernice (2009) EEG coherence: topography and frequency structure. Exp Brain Res 198:59-83
Kamarajan, Chella; Porjesz, Bernice; Rangaswamy, Madhavi et al. (2009) Brain signatures of monetary loss and gain: outcome-related potentials in a single outcome gambling task. Behav Brain Res 197:62-76
Cohen, Howard L; Ji, Jun; Chorlian, David B et al. (2002) Alcohol-related ERP changes recorded from different modalities: a topographic analysis. Alcohol Clin Exp Res 26:303-17
Zhang, X L; Cohen, H L; Porjesz, B et al. (2001) Mismatch negativity in subjects at high risk for alcoholism. Alcohol Clin Exp Res 25:330-7
Prabhu, V R; Porjesz, B; Chorlian, D B et al. (2001) Visual p3 in female alcoholics. Alcohol Clin Exp Res 25:531-9
Wang, K; Begleiter, H; Porjesz, B (2001) Warp-averaging event-related potentials. Clin Neurophysiol 112:1917-24
Wang, K; Begleiter, H; Porjesz, B (2000) Trilinear modeling of event-related potentials. Brain Topogr 12:263-71

Showing the most recent 10 out of 44 publications