Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AA005812-13
Application #
2043342
Study Section
Special Emphasis Panel (NSS)
Project Start
1983-04-01
Project End
1997-07-31
Budget Start
1995-12-01
Budget End
1997-07-31
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Purdue University
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907

  Publications

Mukhopadhyay, Abhijit; Wei, Baoxian; Weiner, Henry (2013) Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol. Biochim Biophys Acta 1830:3391-8
Mukhopadhyay, Abhijit; Yang, Chun-song; Wei, Baoxian et al. (2007) Precursor protein is readily degraded in mitochondrial matrix space if the leader is not processed by mitochondrial processing peptidase. J Biol Chem 282:37266-75
Brichac, Jiri; Ho, Kwok Ki; Honzatko, Ales et al. (2007) Enantioselective oxidation of trans-4-hydroxy-2-nonenal is aldehyde dehydrogenase isozyme and Mg2+ dependent. Chem Res Toxicol 20:887-95
Ho, Kwok Ki; Hurley, Thomas D; Weiner, Henry (2006) Selective alteration of the rate-limiting step in cytosolic aldehyde dehydrogenase through random mutagenesis. Biochemistry 45:9445-53
Mukhopadhyay, Abhijit; Zullo, Steven J; Weiner, Henry (2006) Factors that might affect the allotopic replacement of a damaged mitochondrial DNA-encoded protein. Rejuvenation Res 9:182-90
Rodriguez-Zavala, Jose Salud; Allali-Hassani, Abdellah; Weiner, Henry (2006) Characterization of E. coli tetrameric aldehyde dehydrogenases with atypical properties compared to other aldehyde dehydrogenases. Protein Sci 15:1387-96
Ho, Kwok Ki; Weiner, Henry (2005) Isolation and characterization of an aldehyde dehydrogenase encoded by the aldB gene of Escherichia coli. J Bacteriol 187:1067-73
Ho, Kwok Ki; Allali-Hassani, Abdellah; Hurley, Thomas D et al. (2005) Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases. Biochemistry 44:8022-9
Hammen, Philip K; Allali-Hassani, Abdellah; Hallenga, Klaas et al. (2002) Multiple conformations of NAD and NADH when bound to human cytosolic and mitochondrial aldehyde dehydrogenase. Biochemistry 41:7156-68
Rodriguez-Zavala, Jose S; Weiner, Henry (2002) Structural aspects of aldehyde dehydrogenase that influence dimer-tetramer formation. Biochemistry 41:8229-37

Showing the most recent 10 out of 64 publications