Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AA006610-12
Application #
2043511
Study Section
Special Emphasis Panel (NSS)
Project Start
1989-07-01
Project End
1998-03-31
Budget Start
1996-07-01
Budget End
1998-03-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Biochemistry
Type
Schools of Medicine
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029
Wu, Defeng; Cederbaum, Arthur (2008) Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha-induced liver injury through activation of mitogen-activated protein kinases in mice. Hepatology 47:1005-17
Lu, Yongke; Gong, Pengfei; Cederbaum, Arthur I (2008) Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency. Toxicology 252:9-16
Lu, Yongke; Zhuge, Jian; Wang, Xiaodong et al. (2008) Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology 47:1483-94
Caro, Andres A; Cederbaum, Arthur I (2007) Role of intracellular calcium and phospholipase A2 in arachidonic acid-induced toxicity in liver cells overexpressing CYP2E1. Arch Biochem Biophys 457:252-63
Kessova, Irina G; Cederbaum, Arthur I (2007) Mitochondrial alterations in livers of Sod1-/- mice fed alcohol. Free Radic Biol Med 42:1470-80
Dey, Aparajita; Cederbaum, Arthur I (2007) Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice. Hepatology 45:1355-65
Cederbaum, Arthur I (2006) Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells. J Gastroenterol Hepatol 21 Suppl 3:S22-5
Bai, Jingxiang; Cederbaum, Arthur I (2006) Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice. Toxicol Sci 91:365-71
Zhuge, Jian; Cederbaum, Arthur I (2006) Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1. Free Radic Biol Med 40:63-74
Dey, Aparajita; Cederbaum, Arthur I (2006) Geldanamycin, an inhibitor of Hsp90, potentiates cytochrome P4502E1-mediated toxicity in HepG2 cells. J Pharmacol Exp Ther 317:1391-9

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