Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AA007117-10
Application #
2043696
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1987-02-01
Project End
1997-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Biochemistry
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Sanghani, Paresh C; Robinson, Howard; Bennett-Lovsey, Riccardo et al. (2003) Structure-function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase). Chem Biol Interact 143-144:195-200
Sanghani, Paresh C; Bosron, William F; Hurley, Thomas D (2002) Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation. Biochemistry 41:15189-94
Sanghani, Paresh C; Robinson, Howard; Bosron, William F et al. (2002) Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes. Biochemistry 41:10778-86
Niederhut, M S; Gibbons, B J; Perez-Miller, S et al. (2001) Three-dimensional structures of the three human class I alcohol dehydrogenases. Protein Sci 10:697-706
Ramchandani, V A; Bosron, W F; Li, T K (2001) Research advances in ethanol metabolism. Pathol Biol (Paris) 49:676-82
Sanghani, P C; Stone, C L; Ray, B D et al. (2000) Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase. Biochemistry 39:10720-9
Stone, C L; Jipping, M B; Owusu-Dekyi, K et al. (1999) The pH-dependent binding of NADH and subsequent enzyme isomerization of human liver beta 3 beta 3 alcohol dehydrogenase. Biochemistry 38:5829-35
Kedishvili, N Y; Gough, W H; Davis, W I et al. (1998) Effect of cellular retinol-binding protein on retinol oxidation by human class IV retinol/alcohol dehydrogenase and inhibition by ethanol. Biochem Biophys Res Commun 249:191-6
Yang, Z N; Bosron, W F; Hurley, T D (1997) Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase. J Mol Biol 265:330-43
Kedishvili, N Y; Gough, W H; Chernoff, E A et al. (1997) cDNA sequence and catalytic properties of a chick embryo alcohol dehydrogenase that oxidizes retinol and 3beta,5alpha-hydroxysteroids. J Biol Chem 272:7494-500

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