Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AA007680-13
Application #
6682742
Study Section
Special Emphasis Panel (NSS)
Program Officer
Twombly, Dennis
Project Start
1993-08-01
Project End
2007-04-30
Budget Start
2003-05-01
Budget End
2004-04-30
Support Year
13
Fiscal Year
2003
Total Cost
$263,939
Indirect Cost
Name
University of California Los Angeles
Department
Pharmacology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Lindemeyer, A Kerstin; Shen, Yi; Yazdani, Ferin et al. (2017) ?2 Subunit-Containing GABAA Receptor Subtypes Are Upregulated and Contribute to Alcohol-Induced Functional Plasticity in the Rat Hippocampus. Mol Pharmacol 92:101-112
Wallner, M; Hanchar, H J; Olsen, R W (2014) Alcohol selectivity of ?3-containing GABAA receptors: evidence for a unique extracellular alcohol/imidazobenzodiazepine Ro15-4513 binding site at the ?+?- subunit interface in ??3? GABAA receptors. Neurochem Res 39:1118-26
Liang, Jing; Lindemeyer, A Kerstin; Suryanarayanan, Asha et al. (2014) Plasticity of GABA(A) receptor-mediated neurotransmission in the nucleus accumbens of alcohol-dependent rats. J Neurophysiol 112:39-50
Cushman, Jesse D; Moore, Mellissa D; Olsen, Richard W et al. (2014) The role of the ? GABA(A) receptor in ovarian cycle-linked changes in hippocampus-dependent learning and memory. Neurochem Res 39:1140-6
Liang, Jing; Marty, Vincent N; Mulpuri, Yatendra et al. (2014) Selective modulation of GABAergic tonic current by dopamine in the nucleus accumbens of alcohol-dependent rats. J Neurophysiol 112:51-60
Olsen, Richard W; Li, Guo-Dong; Wallner, Martin et al. (2014) Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol. Alcohol Clin Exp Res 38:595-603
Peng, Zechun; Zhang, Nianhui; Chandra, Dave et al. (2014) Altered localization of the ? subunit of the GABAA receptor in the thalamus of ?4 subunit knockout mice. Neurochem Res 39:1104-17
Davies, Daryl L; Bortolato, Marco; Finn, Deborah A et al. (2013) Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. Alcohol Clin Exp Res 37:8-15
Gonzalez, Claudia; Moss, Stephen J; Olsen, Richard W (2012) Ethanol promotes clathrin adaptor-mediated endocytosis via the intracellular domain of ?-containing GABAA receptors. J Neurosci 32:17874-81
Shen, Yi; Lindemeyer, A Kerstin; Gonzalez, Claudia et al. (2012) Dihydromyricetin as a novel anti-alcohol intoxication medication. J Neurosci 32:390-401

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