Immune Responses to Acetaldehyde Adducts

Klassen, Lynell W.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 4R37AA007818-13
• Application #: 6506082
• Study Section: Special Emphasis Panel (NSS)
• Program Officer: Lucas, Diane
• Project Start: 1989-04-01
• Project End: 2009-05-31
• Budget Start: 2004-06-01
• Budget End: 2005-05-31
• Support Year: 13
• Fiscal Year: 2004
• Total Cost: $264,212

Institution

• Name: University of Nebraska Medical Center
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 168559177
• City: Omaha
• State: NE
• Country: United States
• Zip Code: 68198

Publications

Duryee, Michael J; Willis, Monte S; Schaffert, Courtney S et al. (2014) Precision-cut liver slices from diet-induced obese rats exposed to ethanol are susceptible to oxidative stress and increased fatty acid synthesis. Am J Physiol Gastrointest Liver Physiol 306:G208-17

Thiele, Geoffrey M; Duryee, Michael J; Willis, Monte S et al. (2010) Autoimmune hepatitis induced by syngeneic liver cytosolic proteins biotransformed by alcohol metabolites. Alcohol Clin Exp Res 34:2126-36

Duryee, Michael J; Klassen, Lynell W; Schaffert, Courtney S et al. (2010) Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis. Free Radic Biol Med 49:1480-6

Schaffert, Courtney S; Duryee, Michael J; Bennett, Robert G et al. (2010) Exposure of precision-cut rat liver slices to ethanol accelerates fibrogenesis. Am J Physiol Gastrointest Liver Physiol 299:G661-8

Klassen, Lynell W; Thiele, Geoffrey M; Duryee, Michael J et al. (2008) An in vitro method of alcoholic liver injury using precision-cut liver slices from rats. Biochem Pharmacol 76:426-36

Duryee, Michael J; Klassen, Lynell W; Jones, Bonnie L et al. (2008) Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde. Int Immunopharmacol 8:1112-8

Freeman, Thomas L; Haver, Alvin; Duryee, Michael J et al. (2005) Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysines. Chem Res Toxicol 18:817-24

Thiele, Geoffrey M; Duryee, Michael J; Freeman, Thomas L et al. (2005) Rat sinusoidal liver endothelial cells (SECs) produce pro-fibrotic factors in response to adducts formed from the metabolites of ethanol. Biochem Pharmacol 70:1593-600

Xu, D; Thiele, G M; Beckenhauer, J L et al. (1998) Detection of circulating antibodies to malondialdehyde-acetaldehyde adducts in ethanol-fed rats. Gastroenterology 115:686-92

Xu, D; Thiele, G M; Kearley, M L et al. (1997) Epitope characterization of malondialdehyde-acetaldehyde adducts using an enzyme-linked immunosorbent assay. Chem Res Toxicol 10:978-86