Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AA008608-15
Application #
6732058
Study Section
Special Emphasis Panel (NSS)
Program Officer
Velazquez, Jose M
Project Start
1991-09-25
Project End
2007-02-28
Budget Start
2004-03-01
Budget End
2005-02-28
Support Year
15
Fiscal Year
2004
Total Cost
$373,077
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Physiology
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Jones, Jeffrey P; Joswig-Jones, Carolyn A; Hebner, Michelle et al. (2011) The effects of nitrogen-heme-iron coordination on substrate affinities for cytochrome P450 2E1. Chem Biol Interact 193:50-6
Koop, Dennis R (2006) Alcohol metabolism's damaging effects on the cell: a focus on reactive oxygen generation by the enzyme cytochrome P450 2E1. Alcohol Res Health 29:274-80
DeBarber, Andrea E; Bleyle, Lisa A; Roullet, Jean-Baptiste O et al. (2004) Omega-hydroxylation of farnesol by mammalian cytochromes p450. Biochim Biophys Acta 1682:18-27
Huan, Jian-Ya; Streicher, John M; Bleyle, Lisa A et al. (2004) Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells. Toxicol Appl Pharmacol 199:332-43
Schattenberg, Jorn M; Wang, Yongjun; Rigoli, Raina M et al. (2004) CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling. Hepatology 39:444-55
Spatzenegger, Margit; Liu, Hong; Wang, Qinmi et al. (2003) Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling. J Pharmacol Exp Ther 304:477-87
Isayama, Fuyumi; Froh, Matthias; Bradford, Blair U et al. (2003) The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice. Free Radic Biol Med 35:1568-81
Jones, Brett E; Liu, Hailing; Lo, Chau R et al. (2002) Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress. Antioxid Redox Signal 4:701-9
Wadsworth, T L; McDonald, T L; Koop, D R (2001) Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-alpha. Biochem Pharmacol 62:963-74
Wadsworth, T L; Koop, D R (2001) Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide. Chem Biol Interact 137:43-58

Showing the most recent 10 out of 30 publications