Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AA010630-02
Application #
2047287
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1995-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Pathology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Karahanian, Eduardo; Quintanilla, Maria Elena; Tampier, Lutske et al. (2011) Ethanol as a prodrug: brain metabolism of ethanol mediates its reinforcing effects. Alcohol Clin Exp Res 35:606-12
Quintanilla, Maria Elena; Tampier, Lutske; Sapag, Amalia et al. (2005) Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde levels and voluntary ethanol consumption in rats. Pharmacogenet Genomics 15:427-31
Karahanian, Eduardo; Ocaranza, Paula; Israel, Yedy (2005) Aldehyde dehydrogenase (ALDH2) activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA. Alcohol Clin Exp Res 29:1384-9
Anni, Helen; Pristatsky, Pavlo; Israel, Yedy (2003) Binding of acetaldehyde to a glutathione metabolite: mass spectrometric characterization of an acetaldehyde-cysteinylglycine conjugate. Alcohol Clin Exp Res 27:1613-21
Anni, Helen; Israel, Yedy (2002) Proteomics in alcohol research. Alcohol Res Health 26:219-32
Garver, E; Tu Gc; Cao, Q N et al. (2001) Eliciting the low-activity aldehyde dehydrogenase Asian phenotype by an antisense mechanism results in an aversion to ethanol. J Exp Med 194:571-80
Anni, H; Nikolaeva, O; Israel, Y (2001) Selection of phage-display library peptides recognizing ethanol targets on proteins. Alcohol 25:201-9
Anni, H; Israel, Y (1999) Characterization of adducts of ethanol metabolites with cytochrome c. Alcohol Clin Exp Res 23:26-37