Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AG011385-14
Application #
7216114
Study Section
Special Emphasis Panel (NSS)
Program Officer
Snyder, Stephen D
Project Start
1992-09-01
Project End
2012-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
14
Fiscal Year
2007
Total Cost
$490,830
Indirect Cost
Name
J. David Gladstone Institutes
Department
Type
DUNS #
099992430
City
San Francisco
State
CA
Country
United States
Zip Code
94158
Spencer, Brian; Kim, Changyoun; Gonzalez, Tania et al. (2016) ?-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease. Hum Mol Genet 25:1100-15
Suberbielle, Elsa; Djukic, Biljana; Evans, Mark et al. (2015) DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice. Nat Commun 6:8897
Rockenstein, Edward; Overk, Cassia R; Ubhi, Kiren et al. (2015) A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies. PLoS One 10:e0121570
Dewji, Nazneen N; Singer, S Jonathan; Masliah, Eliezer et al. (2015) Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's disease. PLoS One 10:e0122451
Games, Dora; Valera, Elvira; Spencer, Brian et al. (2014) Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models. J Neurosci 34:9441-54
Borlikova, Gilyana G; Trejo, Margarita; Mably, Alexandra J et al. (2013) Alzheimer brain-derived amyloid ýý-protein impairs synaptic remodeling and memory consolidation. Neurobiol Aging 34:1315-27
Games, Dora; Seubert, Peter; Rockenstein, Edward et al. (2013) Axonopathy in an ?-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated ?-synuclein. Am J Pathol 182:940-53
Suberbielle, Elsa; Sanchez, Pascal E; Kravitz, Alexxai V et al. (2013) Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-?. Nat Neurosci 16:613-21
Sekigawa, Akio; Fujita, Masayo; Sekiyama, Kazunari et al. (2012) Distinct mechanisms of axonal globule formation in mice expressing human wild type ýý-synuclein or dementia with Lewy bodies-linked P123H ýý-synuclein. Mol Brain 5:34
Mandler, Markus; Rockenstein, Edward; Ubhi, Kiren et al. (2012) Detection of peri-synaptic amyloid-? pyroglutamate aggregates in early stages of Alzheimer's disease and in A?PP transgenic mice using a novel monoclonal antibody. J Alzheimers Dis 28:783-94

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