Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI013544-20
Application #
2059990
Study Section
Special Emphasis Panel (NSS)
Project Start
1977-09-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brown University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Tirumalai, R S; Kwon, H J; Cardente, E H et al. (1998) Recognition of core-type DNA sites by lambda integrase. J Mol Biol 279:513-27
Nunes-Duby, S E; Kwon, H J; Tirumalai, R S et al. (1998) Similarities and differences among 105 members of the Int family of site-specific recombinases. Nucleic Acids Res 26:391-406
Tirumalai, R S; Healey, E; Landy, A (1997) The catalytic domain of lambda site-specific recombinase. Proc Natl Acad Sci U S A 94:6104-9
Kwon, H J; Tirumalai, R; Landy, A et al. (1997) Flexibility in DNA recombination: structure of the lambda integrase catalytic core. Science 276:126-31
Nunes-Duby, S E; Yu, D; Landy, A (1997) Sensing homology at the strand-swapping step in lambda excisive recombination. J Mol Biol 272:493-508
Azaro, M A; Landy, A (1997) The isomeric preference of Holliday junctions influences resolution bias by lambda integrase. EMBO J 16:3744-55
Tirumalai, R S; Pargellis, C A; Landy, A (1996) Identification and characterization of the N-ethylmaleimide-sensitive site in lambda-integrase. J Biol Chem 271:29599-604
Zahn, K; Landy, A (1996) Modulation of lambda integrase synthesis by rare arginine tRNA. Mol Microbiol 21:69-76
Nunes-Duby, S E; Azaro, M A; Landy, A (1995) Swapping DNA strands and sensing homology without branch migration in lambda site-specific recombination. Curr Biol 5:139-48
Nunes-Duby, S E; Smith-Mungo, L I; Landy, A (1995) Single base-pair precision and structural rigidity in a small IHF-induced DNA loop. J Mol Biol 253:228-42

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