Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI014627-29
Application #
2060096
Study Section
Special Emphasis Panel (NSS)
Project Start
1988-05-01
Project End
1996-12-31
Budget Start
1996-05-01
Budget End
1996-12-31
Support Year
29
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Novella, Isabel S; Gilbertson, Dorothy L; Borrego, Belen et al. (2005) Adaptability costs in immune escape variants of vesicular stomatitis virus. Virus Res 107:27-34
Novella, I S; Quer, J; Domingo, E et al. (1999) Exponential fitness gains of RNA virus populations are limited by bottleneck effects. J Virol 73:1668-71
Weaver, S C; Brault, A C; Kang, W et al. (1999) Genetic and fitness changes accompanying adaptation of an arbovirus to vertebrate and invertebrate cells. J Virol 73:4316-26
Novella, I S; Hershey, C L; Escarmis, C et al. (1999) Lack of evolutionary stasis during alternating replication of an arbovirus in insect and mammalian cells. J Mol Biol 287:459-65
Holland, J; Domingo, E (1998) Origin and evolution of viruses. Virus Genes 16:13-21
Domingo, E; Holland, J J (1997) RNA virus mutations and fitness for survival. Annu Rev Microbiol 51:151-78
Novella, I S; Cilnis, M; Elena, S F et al. (1996) Large-population passages of vesicular stomatitis virus in interferon-treated cells select variants of only limited resistance. J Virol 70:6414-7
Quer, J; Huerta, R; Novella, I S et al. (1996) Reproducible nonlinear population dynamics and critical points during replicative competitions of RNA virus quasispecies. J Mol Biol 264:465-71
Domingo, E; Escarmis, C; Sevilla, N et al. (1996) Basic concepts in RNA virus evolution. FASEB J 10:859-64
Novella, I S; Elena, S F; Moya, A et al. (1996) Repeated transfer of small RNA virus populations leading to balanced fitness with infrequent stochastic drift. Mol Gen Genet 252:733-8

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